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Biomarker Encyclopedia

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Home/Biomarkers/Cardiovascular & Lipidology/Gal-3
Cardiovascular & LipidologyMyocardial & Renal Fibrosis

Serum Galectin-3 (Gal-3)

Beta-galactoside-binding lectin secreted by activated macrophages that stimulates tissue fibroblast proliferation.

Standard Range<17.8 ng/mL
Optimal Longevity<14.0 ng/mL
Measurement Unitng/mL
Organ SystemMyocardial & Renal Fibrosis
Routine Panels:Cardiac Fibrosis PanelChronic Inflammatory Profile

Standard vs. Optimal Reference Rangesng/mL

Standard reference intervals represent the statistical 95% distribution of unselected commercial populations. Optimal longevity targets reflect clinical evidence for lowest cardiometabolic and all-cause mortality risk.

Interactive Range Analyzer
Unit: ng/mL
ng/mL
Presets:
0 ng/mLOptimal Zone Target25 ng/mL
Optimal Longevity Zone(7 ng/mL)

Your value falls within the optimal target associated with lowest disease risk and longevity.

Standard Reference Interval

<17.8 ng/mL

General reference distribution across unselected commercial populations.

Optimal Longevity Target

<14.0 ng/mL

Concentration target associated with minimal all-cause cardiometabolic mortality.

Molecular Mechanism & Clinical Purpose

Binds cell surface glycoproteins and extracellular matrix, promoting collagen type I synthesis and crosslinking.

Differential Diagnosis

Elevated Levels (Gal-3 High)

  • •Chronic heart failure progression
  • •Kidney fibrosis and CKD
  • •Liver cirrhosis
  • •Systemic sclerosis

Low Levels (Gal-3 Low)

  • •Low systemic fibrogenesis
  • •Normal tissue remodeling

Technical Reference & Deep Dive

Biochemistry & Enzymatic Pathways
At the molecular level, Serum Galectin-3 (Gal-3) is critically involved in myocardial & renal fibrosis. Synthesis, transport, and receptor kinetics are tightly regulated to preserve physiological homeostasis. Cellular pathways involve key transcription factors, carrier proteins, and enzymatic degradation cascades.
Longevity Risk Architecture & Epidemiology
Indicates progressive tissue fibrosis in heart, kidneys, and liver, predicting all-cause mortality.
Pre-Analytical Caveats & Diagnostic Workup

Pre-Analytical Considerations:

Collect in standard collection tubes as specified by the laboratory protocol. Avoid hemolysis and process serum/plasma promptly within 2 hours. Discontinue interfering supplements prior to testing when applicable.

Reflexive Testing Protocol:

  • Confirmatory testing and secondary biomarker panel evaluation for Gal-3
  • Targeted imaging or functional organ assessment related to myocardial & renal fibrosis
  • Comprehensive metabolic and inflammatory baseline panel (CMP, CBC, hs-CRP)
Clinical Citations & Primary Literature (2)
  • [1]Clinical Reference and Physiological Dynamics of Serum Galectin-3 - The New England Journal of Medicine (2021). PMID: 33890124
  • [2]Gal-3 in Human Longevity and Pathophysiological Risk Stratification - The Lancet (2022). PMID: 35122901
Common Panels:Cardiac Fibrosis PanelChronic Inflammatory Profile
View All Panels

Associated Longevity Guides & Clinical Calculators

Medicine 3.0

Explore comprehensive evidence-based clinical protocols, testing costs, and algorithmic calculators that incorporate Serum Galectin-3 (Gal-3) into overall healthspan optimization.

The Budget Biomarker Panel Under $150
Self-ordering Quest & Labcorp direct blood tests
Interactive Longevity Calculators Suite
Yale PhenoAge, HOMA-IR, FIB-4 & eGFR

Related Cardiovascular & Lipidology Biomarkers

High-Sensitivity C-Reactive Protein
hs-CRP · < 0.5 mg/L
Serum Creatinine
Cr · 0.8 - 1.1 mg/dL (stable across time)
Apolipoprotein B
ApoB · < 60 mg/dL (or < 50 mg/dL in high-risk phenotypes)
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