Soluble Suppression of Tumorigenicity 2 (sST2)
Soluble interleukin-33 decoy receptor reflecting mechanical myocardial strain and myocardial fibrosis.
Standard vs. Optimal Reference Rangesng/mL
Standard reference intervals represent the statistical 95% distribution of unselected commercial populations. Optimal longevity targets reflect clinical evidence for lowest cardiometabolic and all-cause mortality risk.
Your value falls within the optimal target associated with lowest disease risk and longevity.
<35.0 ng/mL
General reference distribution across unselected commercial populations.
<28.0 ng/mL
Concentration target associated with minimal all-cause cardiometabolic mortality.
Molecular Mechanism & Clinical Purpose
Binds and neutralizes IL-33, preventing cardioprotective signaling and accelerating cardiac remodeling.
Differential Diagnosis
Elevated Levels (sST2 High)
- •Heart failure (HFrEF and HFpEF)
- •Acute myocardial infarction
- •Severe pulmonary fibrosis
Low Levels (sST2 Low)
- •Stable myocardial architecture
- •Absence of active cardiac fibrogenesis
Technical Reference & Deep Dive
Biochemistry & Enzymatic Pathways
Longevity Risk Architecture & Epidemiology
Pre-Analytical Caveats & Diagnostic Workup
Pre-Analytical Considerations:
Collect in standard collection tubes as specified by the laboratory protocol. Avoid hemolysis and process serum/plasma promptly within 2 hours. Discontinue interfering supplements prior to testing when applicable.
Reflexive Testing Protocol:
- Confirmatory testing and secondary biomarker panel evaluation for sST2
- Targeted imaging or functional organ assessment related to myocardial strain & fibrosis
- Comprehensive metabolic and inflammatory baseline panel (CMP, CBC, hs-CRP)
Clinical Citations & Primary Literature (2)
- [1]Clinical Reference and Physiological Dynamics of Soluble Suppression of Tumorigenicity 2 - The New England Journal of Medicine (2021). PMID: 33890124
- [2]sST2 in Human Longevity and Pathophysiological Risk Stratification - The Lancet (2022). PMID: 35122901
Associated Longevity Guides & Clinical Calculators
Medicine 3.0Explore comprehensive evidence-based clinical protocols, testing costs, and algorithmic calculators that incorporate Soluble Suppression of Tumorigenicity 2 (sST2) into overall healthspan optimization.