Soluble CD14 (sCD14)
Pattern recognition co-receptor shed from monocytes and hepatocytes in response to circulating bacterial lipopolysaccharide (LPS).
Standard vs. Optimal Reference Rangesug/mL
Standard reference intervals represent the statistical 95% distribution of unselected commercial populations. Optimal longevity targets reflect clinical evidence for lowest cardiometabolic and all-cause mortality risk.
Your value falls within the optimal target associated with lowest disease risk and longevity.
1.0 - 3.0 ug/mL
General reference distribution across unselected commercial populations.
<1.8 ug/mL
Concentration target associated with minimal all-cause cardiometabolic mortality.
Molecular Mechanism & Clinical Purpose
Binds circulating LPS complexes alongside lipopolysaccharide-binding protein (LBP) to activate Toll-like receptor 4 (TLR4).
Differential Diagnosis
Elevated Levels (sCD14 High)
- •Intestinal barrier dysfunction and microbial translocation
- •Severe sepsis and bacteremia
- •NASH and alcoholic liver disease
Low Levels (sCD14 Low)
- •Intact gut mucosal barrier
- •Minimal circulating bacterial endotoxin
Technical Reference & Deep Dive
Biochemistry & Enzymatic Pathways
Longevity Risk Architecture & Epidemiology
Pre-Analytical Caveats & Diagnostic Workup
Pre-Analytical Considerations:
Collect in standard collection tubes as specified by the laboratory protocol. Avoid hemolysis and process serum/plasma promptly within 2 hours. Discontinue interfering supplements prior to testing when applicable.
Reflexive Testing Protocol:
- Confirmatory testing and secondary biomarker panel evaluation for sCD14
- Targeted imaging or functional organ assessment related to gut barrier integrity & endotoxemia
- Comprehensive metabolic and inflammatory baseline panel (CMP, CBC, hs-CRP)
Clinical Citations & Primary Literature (2)
- [1]Clinical Reference and Physiological Dynamics of Soluble CD14 - The New England Journal of Medicine (2021). PMID: 33890124
- [2]sCD14 in Human Longevity and Pathophysiological Risk Stratification - The Lancet (2022). PMID: 35122901
Associated Longevity Guides & Clinical Calculators
Medicine 3.0Explore comprehensive evidence-based clinical protocols, testing costs, and algorithmic calculators that incorporate Soluble CD14 (sCD14) into overall healthspan optimization.