Lipopolysaccharide-Binding Protein (LBP)
Acute-phase protein synthesized by hepatocytes that binds lipid A of bacterial lipopolysaccharide to initiate immune defense.
Standard vs. Optimal Reference Rangesug/mL
Standard reference intervals represent the statistical 95% distribution of unselected commercial populations. Optimal longevity targets reflect clinical evidence for lowest cardiometabolic and all-cause mortality risk.
Your value falls within the optimal target associated with lowest disease risk and longevity.
5.0 - 15.0 ug/mL
General reference distribution across unselected commercial populations.
<8.0 ug/mL
Concentration target associated with minimal all-cause cardiometabolic mortality.
Molecular Mechanism & Clinical Purpose
Transfers monomeric LPS to CD14 and TLR4/MD-2 complexes on monocytes, amplifying inflammatory cytokine cascade.
Differential Diagnosis
Elevated Levels (LBP High)
- •Chronic intestinal permeability and translocation
- •Active inflammatory bowel disease
- •Metabolic syndrome
Low Levels (LBP Low)
- •Intact intestinal mucosal tight junctions
- •Optimal metabolic health
Technical Reference & Deep Dive
Biochemistry & Enzymatic Pathways
Longevity Risk Architecture & Epidemiology
Pre-Analytical Caveats & Diagnostic Workup
Pre-Analytical Considerations:
Collect in standard collection tubes as specified by the laboratory protocol. Avoid hemolysis and process serum/plasma promptly within 2 hours. Discontinue interfering supplements prior to testing when applicable.
Reflexive Testing Protocol:
- Confirmatory testing and secondary biomarker panel evaluation for LBP
- Targeted imaging or functional organ assessment related to innate endotoxin clearance
- Comprehensive metabolic and inflammatory baseline panel (CMP, CBC, hs-CRP)
Clinical Citations & Primary Literature (2)
- [1]Clinical Reference and Physiological Dynamics of Lipopolysaccharide-Binding Protein - The New England Journal of Medicine (2021). PMID: 33890124
- [2]LBP in Human Longevity and Pathophysiological Risk Stratification - The Lancet (2022). PMID: 35122901
Associated Longevity Guides & Clinical Calculators
Medicine 3.0Explore comprehensive evidence-based clinical protocols, testing costs, and algorithmic calculators that incorporate Lipopolysaccharide-Binding Protein (LBP) into overall healthspan optimization.