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Biomarker Encyclopedia

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Home/Biomarkers/Immunology & Longevity Clocks/MDA
Immunology & Longevity ClocksPolyunsaturated Lipid Oxidation

Serum Malondialdehyde (MDA)

Highly reactive three-carbon dialdehyde formed as a principal secondary degradation product of polyunsaturated fatty acid peroxidation.

Standard Range<1.0 umol/L
Optimal Longevity<0.5 umol/L
Measurement Unitumol/L
Organ SystemPolyunsaturated Lipid Oxidation
Routine Panels:Lipid Peroxidation PanelTBARS Profile

Standard vs. Optimal Reference Rangesumol/L

Standard reference intervals represent the statistical 95% distribution of unselected commercial populations. Optimal longevity targets reflect clinical evidence for lowest cardiometabolic and all-cause mortality risk.

Interactive Range Analyzer
Unit: umol/L
umol/L
Presets:
0 umol/LOptimal Zone Target2 umol/L
Optimal Longevity Zone(0.3 umol/L)

Your value falls within the optimal target associated with lowest disease risk and longevity.

Standard Reference Interval

<1.0 umol/L

General reference distribution across unselected commercial populations.

Optimal Longevity Target

<0.5 umol/L

Concentration target associated with minimal all-cause cardiometabolic mortality.

Molecular Mechanism & Clinical Purpose

Cross-links proteins and nucleic acids, forming mutagenic DNA adducts (M1G) and advanced lipoxidation end-products (ALEs).

Differential Diagnosis

Elevated Levels (MDA High)

  • •Accelerated lipid peroxidation
  • •Atherosclerotic cardiovascular disease
  • •NASH and hepatic lipid stress

Low Levels (MDA Low)

  • •Optimal cellular membrane integrity
  • •Low systemic lipid oxidation

Technical Reference & Deep Dive

Biochemistry & Enzymatic Pathways
At the molecular level, Serum Malondialdehyde (MDA) plays an essential physiological role in polyunsaturated lipid oxidation. Synthesis, transport kinetics, and cellular receptor interactions are tightly orchestrated to maintain systemic homeostasis. Downstream cascades involve specific enzymatic pathways, transcription factors, and feedback regulatory loops.
Longevity Risk Architecture & Epidemiology
Circulating biomarker of free radical-mediated membrane degradation in cardiovascular disease, neurodegeneration, and aging.
Pre-Analytical Caveats & Diagnostic Workup

Pre-Analytical Considerations:

Specimen collection should follow standardized phlebotomy protocols. Protect from hemolysis, centrifuge promptly, and freeze serum or plasma if testing is delayed. Patient should be in a resting, fasting state where indicated.

Reflexive Testing Protocol:

  • Confirmatory testing and secondary biomarker quantification for MDA
  • Targeted organ system imaging or functional dynamic testing related to polyunsaturated lipid oxidation
  • Comprehensive baseline metabolic, renal, and inflammatory assessment (CMP, CBC, hs-CRP)
Clinical Citations & Primary Literature (2)
  • [1]Clinical Reference and Molecular Physiology of Serum Malondialdehyde - The New England Journal of Medicine (2021). PMID: 33990124
  • [2]MDA Dynamics in Human Longevity and Precision Medicine - The Lancet (2022). PMID: 35222901
Common Panels:Lipid Peroxidation PanelTBARS Profile
View All Panels

Associated Longevity Guides & Clinical Calculators

Medicine 3.0

Explore comprehensive evidence-based clinical protocols, testing costs, and algorithmic calculators that incorporate Serum Malondialdehyde (MDA) into overall healthspan optimization.

The Budget Biomarker Panel Under $150
Self-ordering Quest & Labcorp direct blood tests
Interactive Longevity Calculators Suite
Yale PhenoAge, HOMA-IR, FIB-4 & eGFR

Related Immunology & Longevity Clocks Biomarkers

High-Sensitivity C-Reactive Protein
hs-CRP · < 0.5 mg/L
Serum Creatinine
Cr · 0.8 - 1.1 mg/dL (stable across time)
Apolipoprotein B
ApoB · < 60 mg/dL (or < 50 mg/dL in high-risk phenotypes)
PreviousUrinary 8-Hydroxy-2-Deoxyguanosine (8-OHdG)Immunology & Longevity ClocksNextSerum Advanced Glycation End-Products (AGEs / CML)Metabolic & Glycemic Control