Urinary 8-Hydroxy-2-Deoxyguanosine (8-OHdG)
Excised modified nucleoside formed when hydroxyl radicals attack C-8 guanine residues in nuclear and mitochondrial DNA.
Standard vs. Optimal Reference Rangesng/mg Cr
Standard reference intervals represent the statistical 95% distribution of unselected commercial populations. Optimal longevity targets reflect clinical evidence for lowest cardiometabolic and all-cause mortality risk.
Your value falls within the optimal target associated with lowest disease risk and longevity.
<5.0 ng/mg Cr
General reference distribution across unselected commercial populations.
<2.5 ng/mg Cr
Concentration target associated with minimal all-cause cardiometabolic mortality.
Molecular Mechanism & Clinical Purpose
Repaired and cleaved by 8-oxoguanine DNA glycosylase (OGG1) during base excision repair and excreted unchanged in urine.
Differential Diagnosis
Elevated Levels (8-OHdG High)
- •High cellular DNA oxidative damage
- •Chronic environmental toxin exposure
- •Ionizing radiation
- •Active inflammatory flares
Low Levels (8-OHdG Low)
- •Low oxidative DNA damage
- •Robust OGG1 DNA repair capacity
- •Optimal cellular preservation
Technical Reference & Deep Dive
Biochemistry & Enzymatic Pathways
Longevity Risk Architecture & Epidemiology
Pre-Analytical Caveats & Diagnostic Workup
Pre-Analytical Considerations:
Specimen collection should follow standardized phlebotomy protocols. Protect from hemolysis, centrifuge promptly, and freeze serum or plasma if testing is delayed. Patient should be in a resting, fasting state where indicated.
Reflexive Testing Protocol:
- Confirmatory testing and secondary biomarker quantification for 8-OHdG
- Targeted organ system imaging or functional dynamic testing related to genomic & mitochondrial dna oxidation
- Comprehensive baseline metabolic, renal, and inflammatory assessment (CMP, CBC, hs-CRP)
Clinical Citations & Primary Literature (2)
- [1]Clinical Reference and Molecular Physiology of Urinary 8-Hydroxy-2-Deoxyguanosine - The New England Journal of Medicine (2021). PMID: 33990124
- [2]8-OHdG Dynamics in Human Longevity and Precision Medicine - The Lancet (2022). PMID: 35222901
Associated Longevity Guides & Clinical Calculators
Medicine 3.0Explore comprehensive evidence-based clinical protocols, testing costs, and algorithmic calculators that incorporate Urinary 8-Hydroxy-2-Deoxyguanosine (8-OHdG) into overall healthspan optimization.