Ionized Calcium (Free Ca2+) (iCa)
Physiologically active, unbound ionized fraction of calcium governing neuromuscular excitability and cardiac electrophysiology.
Standard vs. Optimal Reference Rangesmmol/L
Standard reference intervals represent the statistical 95% distribution of unselected commercial populations. Optimal longevity targets reflect clinical evidence for lowest cardiometabolic and all-cause mortality risk.
Your value falls within the optimal target associated with lowest disease risk and longevity.
1.15 - 1.33 mmol/L (4.6 - 5.3 mg/dL)
General reference distribution across unselected commercial populations.
1.18 - 1.28 mmol/L
Concentration target associated with minimal all-cause cardiometabolic mortality.
Molecular Mechanism & Clinical Purpose
Represents ~50% of total serum calcium, unaffected by fluctuations in circulating albumin concentrations.
Differential Diagnosis
Elevated Levels (iCa High)
- •Primary hyperparathyroidism
- •Hypercalcemia of malignancy
- •Vitamin D intoxication
- •Sarcoidosis granulomas
Low Levels (iCa Low)
- •Hypoparathyroidism
- •Severe vitamin D deficiency
- •Acute pancreatitis
- •Massive citrated blood transfusion
Technical Reference & Deep Dive
Biochemistry & Enzymatic Pathways
Longevity Risk Architecture & Epidemiology
Pre-Analytical Caveats & Diagnostic Workup
Pre-Analytical Considerations:
Collect in standard collection tubes as specified by the laboratory protocol. Avoid hemolysis and process serum/plasma promptly within 2 hours. Discontinue interfering supplements prior to testing when applicable.
Reflexive Testing Protocol:
- Confirmatory testing and secondary biomarker panel evaluation for iCa
- Targeted imaging or functional organ assessment related to physiologically active calcium
- Comprehensive metabolic and inflammatory baseline panel (CMP, CBC, hs-CRP)
Clinical Citations & Primary Literature (2)
- [1]Clinical Reference and Physiological Dynamics of Ionized Calcium (Free Ca2+) - The New England Journal of Medicine (2021). PMID: 33890124
- [2]iCa in Human Longevity and Pathophysiological Risk Stratification - The Lancet (2022). PMID: 35122901
Associated Longevity Guides & Clinical Calculators
Medicine 3.0Explore comprehensive evidence-based clinical protocols, testing costs, and algorithmic calculators that incorporate Ionized Calcium (Free Ca2+) (iCa) into overall healthspan optimization.