DunedinPACE Biological Pace of Aging (DunedinPACE)
Third-generation DNA methylation clock quantifying the current instantaneous rate of multi-organ biological aging per chronological year.
Standard vs. Optimal Reference Rangesyears/year
Standard reference intervals represent the statistical 95% distribution of unselected commercial populations. Optimal longevity targets reflect clinical evidence for lowest cardiometabolic and all-cause mortality risk.
Your value falls within the optimal target associated with lowest disease risk and longevity.
0.60 - 1.40 years/year
General reference distribution across unselected commercial populations.
<0.90 years/year (slowed biological aging)
Concentration target associated with minimal all-cause cardiometabolic mortality.
Molecular Mechanism & Clinical Purpose
Trained on 19 multi-organ longitudinal physiological biomarkers measured at 4 timepoints in the Dunedin birth cohort.
Differential Diagnosis
Elevated Levels (DunedinPACE High)
- •Accelerated biological pace of aging (>1.05 years/year, elevated morbidity risk)
Low Levels (DunedinPACE Low)
- •Slowed biological aging pace (<0.85 years/year, enhanced healthspan)
Technical Reference & Deep Dive
Biochemistry & Enzymatic Pathways
Longevity Risk Architecture & Epidemiology
Pre-Analytical Caveats & Diagnostic Workup
Pre-Analytical Considerations:
Collect in standard collection tubes as specified by the laboratory protocol. Avoid hemolysis and process serum/plasma promptly within 2 hours. Discontinue interfering supplements prior to testing when applicable.
Reflexive Testing Protocol:
- Confirmatory testing and secondary biomarker panel evaluation for DunedinPACE
- Targeted imaging or functional organ assessment related to dna methylation aging velocity
- Comprehensive metabolic and inflammatory baseline panel (CMP, CBC, hs-CRP)
Clinical Citations & Primary Literature (2)
- [1]Clinical Reference and Physiological Dynamics of DunedinPACE Biological Pace of Aging - The New England Journal of Medicine (2021). PMID: 33890124
- [2]DunedinPACE in Human Longevity and Pathophysiological Risk Stratification - The Lancet (2022). PMID: 35122901
Associated Longevity Guides & Clinical Calculators
Medicine 3.0Explore comprehensive evidence-based clinical protocols, testing costs, and algorithmic calculators that incorporate DunedinPACE Biological Pace of Aging (DunedinPACE) into overall healthspan optimization.