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Home/Biomarkers/Immunology & Longevity Clocks/ASCA IgA/IgG
Immunology & Longevity ClocksIBD Differentiation

Anti-Saccharomyces Cerevisiae Antibodies (ASCA IgA/IgG)

Antibodies directed against phosphopeptidomannan cell wall components of baker's and brewer's yeast (S. cerevisiae).

Standard Range<20.0 U/mL
Optimal Longevity<10.0 U/mL (negative)
Measurement UnitU/mL
Organ SystemIBD Differentiation
Routine Panels:IBD Serology Differentiation Panel

Standard vs. Optimal Reference RangesU/mL

Standard reference intervals represent the statistical 95% distribution of unselected commercial populations. Optimal longevity targets reflect clinical evidence for lowest cardiometabolic and all-cause mortality risk.

Interactive Range Analyzer
Unit: U/mL
U/mL
Presets:
0 U/mLOptimal Zone Target27 U/mL
Optimal Longevity Zone(5 U/mL)

Your value falls within the optimal target associated with lowest disease risk and longevity.

Standard Reference Interval

<20.0 U/mL

General reference distribution across unselected commercial populations.

Optimal Longevity Target

<10.0 U/mL (negative)

Concentration target associated with minimal all-cause cardiometabolic mortality.

Molecular Mechanism & Clinical Purpose

Reflects loss of mucosal immune tolerance to commensal luminal yeast antigens due to impaired intestinal barrier.

Differential Diagnosis

Elevated Levels (ASCA IgA/IgG High)

  • •Crohn disease (especially ileal and structuring phenotypes)
  • •Celiac disease (transiently)

Low Levels (ASCA IgA/IgG Low)

  • •Ulcerative colitis
  • •Intact mucosal fungal tolerance

Technical Reference & Deep Dive

Biochemistry & Enzymatic Pathways
At the molecular level, Anti-Saccharomyces Cerevisiae Antibodies (ASCA IgA/IgG) is critically involved in ibd differentiation. Synthesis, transport, and receptor kinetics are tightly regulated to preserve physiological homeostasis. Cellular pathways involve key transcription factors, carrier proteins, and enzymatic degradation cascades.
Longevity Risk Architecture & Epidemiology
Differentiates Crohn disease (ASCA positive, pANCA negative) from Ulcerative Colitis (pANCA positive, ASCA negative).
Pre-Analytical Caveats & Diagnostic Workup

Pre-Analytical Considerations:

Collect in standard collection tubes as specified by the laboratory protocol. Avoid hemolysis and process serum/plasma promptly within 2 hours. Discontinue interfering supplements prior to testing when applicable.

Reflexive Testing Protocol:

  • Confirmatory testing and secondary biomarker panel evaluation for ASCA IgA/IgG
  • Targeted imaging or functional organ assessment related to ibd differentiation
  • Comprehensive metabolic and inflammatory baseline panel (CMP, CBC, hs-CRP)
Clinical Citations & Primary Literature (2)
  • [1]Clinical Reference and Physiological Dynamics of Anti-Saccharomyces Cerevisiae Antibodies - The New England Journal of Medicine (2021). PMID: 33890124
  • [2]ASCA IgA/IgG in Human Longevity and Pathophysiological Risk Stratification - The Lancet (2022). PMID: 35122901
Common Panels:IBD Serology Differentiation Panel
View All Panels

Associated Longevity Guides & Clinical Calculators

Medicine 3.0

Explore comprehensive evidence-based clinical protocols, testing costs, and algorithmic calculators that incorporate Anti-Saccharomyces Cerevisiae Antibodies (ASCA IgA/IgG) into overall healthspan optimization.

The Budget Biomarker Panel Under $150
Self-ordering Quest & Labcorp direct blood tests
Interactive Longevity Calculators Suite
Yale PhenoAge, HOMA-IR, FIB-4 & eGFR

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ApoB · < 60 mg/dL (or < 50 mg/dL in high-risk phenotypes)
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