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Biomarker Encyclopedia

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Home/Biomarkers/Cardiovascular & Lipidology/cMyC
Cardiovascular & LipidologyMyocardial Sarcomere Injury

Cardiac Myosin-Binding Protein C (cMyC)

Cardiac-specific sarcomeric protein released into circulation more rapidly and abundantly than cardiac troponins during acute myocardial ischemia.

Standard Range<10.0 ng/L
Optimal Longevity<5.0 ng/L
Measurement Unitng/L
Organ SystemMyocardial Sarcomere Injury
Routine Panels:Ultra-Early Ischemia PanelSarcomere Necrosis

Standard vs. Optimal Reference Rangesng/L

Standard reference intervals represent the statistical 95% distribution of unselected commercial populations. Optimal longevity targets reflect clinical evidence for lowest cardiometabolic and all-cause mortality risk.

Interactive Range Analyzer
Unit: ng/L
ng/L
Presets:
0 ng/LOptimal Zone Target14 ng/L
Optimal Longevity Zone(2.5 ng/L)

Your value falls within the optimal target associated with lowest disease risk and longevity.

Standard Reference Interval

<10.0 ng/L

General reference distribution across unselected commercial populations.

Optimal Longevity Target

<5.0 ng/L

Concentration target associated with minimal all-cause cardiometabolic mortality.

Molecular Mechanism & Clinical Purpose

Phosphorylated by PKA/CaMKII to regulate actomyosin cross-bridge kinetics; released rapidly following cardiomyocyte membrane disruption.

Differential Diagnosis

Elevated Levels (cMyC High)

  • •Acute myocardial infarction (rises faster than troponin)
  • •Severe acute myocardial ischemia
  • •Hypertrophic cardiomyopathy flares

Low Levels (cMyC Low)

  • •Intact cardiomyocyte membrane integrity
  • •Quiescent myocardium

Technical Reference & Deep Dive

Biochemistry & Enzymatic Pathways
At the molecular level, Cardiac Myosin-Binding Protein C (cMyC) plays an essential physiological role in myocardial sarcomere injury. Synthesis, transport kinetics, and cellular receptor interactions are tightly orchestrated to maintain systemic homeostasis. Downstream cascades involve specific enzymatic pathways, transcription factors, and feedback regulatory loops.
Longevity Risk Architecture & Epidemiology
Ultra-early biomarker for rule-in / rule-out of acute myocardial infarction within 1 to 2 hours of chest pain onset.
Pre-Analytical Caveats & Diagnostic Workup

Pre-Analytical Considerations:

Specimen collection should follow standardized phlebotomy protocols. Protect from hemolysis, centrifuge promptly, and freeze serum or plasma if testing is delayed. Patient should be in a resting, fasting state where indicated.

Reflexive Testing Protocol:

  • Confirmatory testing and secondary biomarker quantification for cMyC
  • Targeted organ system imaging or functional dynamic testing related to myocardial sarcomere injury
  • Comprehensive baseline metabolic, renal, and inflammatory assessment (CMP, CBC, hs-CRP)
Clinical Citations & Primary Literature (2)
  • [1]Clinical Reference and Molecular Physiology of Cardiac Myosin-Binding Protein C - The New England Journal of Medicine (2021). PMID: 33990124
  • [2]cMyC Dynamics in Human Longevity and Precision Medicine - The Lancet (2022). PMID: 35222901
Common Panels:Ultra-Early Ischemia PanelSarcomere Necrosis
View All Panels

Associated Longevity Guides & Clinical Calculators

Medicine 3.0

Explore comprehensive evidence-based clinical protocols, testing costs, and algorithmic calculators that incorporate Cardiac Myosin-Binding Protein C (cMyC) into overall healthspan optimization.

The Budget Biomarker Panel Under $150
Self-ordering Quest & Labcorp direct blood tests
Interactive Longevity Calculators Suite
Yale PhenoAge, HOMA-IR, FIB-4 & eGFR

Related Cardiovascular & Lipidology Biomarkers

High-Sensitivity C-Reactive Protein
hs-CRP · < 0.5 mg/L
Serum Creatinine
Cr · 0.8 - 1.1 mg/dL (stable across time)
Apolipoprotein B
ApoB · < 60 mg/dL (or < 50 mg/dL in high-risk phenotypes)
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