Plasma Angiotensin II (Ang II)
Octapeptide cleaved from angiotensin I by ACE that acts as the master effector peptide of the renin-angiotensin system.
Standard vs. Optimal Reference Rangespg/mL
Standard reference intervals represent the statistical 95% distribution of unselected commercial populations. Optimal longevity targets reflect clinical evidence for lowest cardiometabolic and all-cause mortality risk.
Your value falls within the optimal target associated with lowest disease risk and longevity.
10 - 40 pg/mL
General reference distribution across unselected commercial populations.
12 - 25 pg/mL
Concentration target associated with minimal all-cause cardiometabolic mortality.
Molecular Mechanism & Clinical Purpose
Binds AT1 receptors to stimulate vasoconstriction, aldosterone release, oxidative stress via NADPH oxidase, and cardiac hypertrophy.
Differential Diagnosis
Elevated Levels (Ang II High)
- •Renovascular hypertension
- •Congestive heart failure
- •Dehydration / hypovolemia
- •Untreated renal artery stenosis
Low Levels (Ang II Low)
- •ACE inhibitor therapy (blocks Ang I to Ang II conversion)
- •Volume overload
- •Primary aldosteronism suppression
Technical Reference & Deep Dive
Biochemistry & Enzymatic Pathways
Longevity Risk Architecture & Epidemiology
Pre-Analytical Caveats & Diagnostic Workup
Pre-Analytical Considerations:
Specimen collection should follow standardized phlebotomy protocols. Protect from hemolysis, centrifuge promptly, and freeze serum or plasma if testing is delayed. Patient should be in a resting, fasting state where indicated.
Reflexive Testing Protocol:
- Confirmatory testing and secondary biomarker quantification for Ang II
- Targeted organ system imaging or functional dynamic testing related to vascular tone & tissue remodeling
- Comprehensive baseline metabolic, renal, and inflammatory assessment (CMP, CBC, hs-CRP)
Clinical Citations & Primary Literature (2)
- [1]Clinical Reference and Molecular Physiology of Plasma Angiotensin II - The New England Journal of Medicine (2021). PMID: 33990124
- [2]Ang II Dynamics in Human Longevity and Precision Medicine - The Lancet (2022). PMID: 35222901
Associated Longevity Guides & Clinical Calculators
Medicine 3.0Explore comprehensive evidence-based clinical protocols, testing costs, and algorithmic calculators that incorporate Plasma Angiotensin II (Ang II) into overall healthspan optimization.