Arginine Vasopressin (Antidiuretic Hormone) (AVP / ADH)
Nonapeptide neurohormone synthesized in hypothalamus that regulates plasma osmolality and renal free water reabsorption.
Standard vs. Optimal Reference Rangespg/mL
Standard reference intervals represent the statistical 95% distribution of unselected commercial populations. Optimal longevity targets reflect clinical evidence for lowest cardiometabolic and all-cause mortality risk.
Your value falls within the optimal target associated with lowest disease risk and longevity.
1.0 - 5.0 pg/mL (normal plasma osmolality)
General reference distribution across unselected commercial populations.
1.5 - 3.5 pg/mL
Concentration target associated with minimal all-cause cardiometabolic mortality.
Molecular Mechanism & Clinical Purpose
Binds V2 receptors on renal collecting duct principal cells, triggering aquaporin-2 (AQP2) water channel apical membrane insertion.
Differential Diagnosis
Elevated Levels (AVP / ADH High)
- •Syndrome of Inappropriate Antidiuretic Hormone (SIADH)
- •Severe intravascular hypovolemia / shock
- •Heart failure (baroreceptor-mediated non-osmotic release)
Low Levels (AVP / ADH Low)
- •Central Diabetes Insipidus (hypothalamic-pituitary failure)
- •Water intoxication / extreme overhydration
Technical Reference & Deep Dive
Biochemistry & Enzymatic Pathways
Longevity Risk Architecture & Epidemiology
Pre-Analytical Caveats & Diagnostic Workup
Pre-Analytical Considerations:
Specimen collection should follow standardized phlebotomy protocols. Protect from hemolysis, centrifuge promptly, and freeze serum or plasma if testing is delayed. Patient should be in a resting, fasting state where indicated.
Reflexive Testing Protocol:
- Confirmatory testing and secondary biomarker quantification for AVP / ADH
- Targeted organ system imaging or functional dynamic testing related to renal osmoregulation & water reabsorption
- Comprehensive baseline metabolic, renal, and inflammatory assessment (CMP, CBC, hs-CRP)
Clinical Citations & Primary Literature (2)
- [1]Clinical Reference and Molecular Physiology of Arginine Vasopressin (Antidiuretic Hormone) - The New England Journal of Medicine (2021). PMID: 33990124
- [2]AVP / ADH Dynamics in Human Longevity and Precision Medicine - The Lancet (2022). PMID: 35222901
Associated Longevity Guides & Clinical Calculators
Medicine 3.0Explore comprehensive evidence-based clinical protocols, testing costs, and algorithmic calculators that incorporate Arginine Vasopressin (Antidiuretic Hormone) (AVP / ADH) into overall healthspan optimization.