Urinary Suberic Acid (Suberate)
Eight-carbon dicarboxylic acid generated when medium-chain monocarboxylic fatty acids (octanoic acid) undergo omega-oxidation.
Standard vs. Optimal Reference Rangesug/mg Cr
Standard reference intervals represent the statistical 95% distribution of unselected commercial populations. Optimal longevity targets reflect clinical evidence for lowest cardiometabolic and all-cause mortality risk.
Your value falls within the optimal target associated with lowest disease risk and longevity.
<2.0 ug/mg Cr
General reference distribution across unselected commercial populations.
<1.0 ug/mg Cr
Concentration target associated with minimal all-cause cardiometabolic mortality.
Molecular Mechanism & Clinical Purpose
Forms under conditions where medium-chain acyl-CoA dehydrogenase (MCAD) is deficient or mitochondrial beta-oxidation is overwhelmed.
Differential Diagnosis
Elevated Levels (Suberate High)
- •Medium-Chain Acyl-CoA Dehydrogenase (MCAD) Deficiency
- •Mitochondrial electron transport chain overload
- •Diabetic ketoacidosis
Low Levels (Suberate Low)
- •Normal medium-chain fatty acid beta-oxidation
- •Optimal mitochondrial oxidation
Technical Reference & Deep Dive
Biochemistry & Enzymatic Pathways
Longevity Risk Architecture & Epidemiology
Pre-Analytical Caveats & Diagnostic Workup
Pre-Analytical Considerations:
Specimen collection should follow standardized phlebotomy protocols. Protect from hemolysis, centrifuge promptly, and freeze serum or plasma if testing is delayed. Patient should be in a resting, fasting state where indicated.
Reflexive Testing Protocol:
- Confirmatory testing and secondary biomarker quantification for Suberate
- Targeted organ system imaging or functional dynamic testing related to medium-chain dicarboxylic acid oxidation
- Comprehensive baseline metabolic, renal, and inflammatory assessment (CMP, CBC, hs-CRP)
Clinical Citations & Primary Literature (2)
- [1]Clinical Reference and Molecular Physiology of Urinary Suberic Acid - The New England Journal of Medicine (2021). PMID: 34190124
- [2]Suberate Dynamics in Human Longevity and Precision Medicine - The Lancet (2022). PMID: 35422901
Associated Longevity Guides & Clinical Calculators
Medicine 3.0Explore comprehensive evidence-based clinical protocols, testing costs, and algorithmic calculators that incorporate Urinary Suberic Acid (Suberate) into overall healthspan optimization.