Soluble MAC (sC5b-9) (sC5b-9)
Soluble circulating multi-protein complex composed of complement components C5b, C6, C7, C8, C9, and regulatory S-protein (vitronectin).
Standard vs. Optimal Reference Rangesng/mL
Standard reference intervals represent the statistical 95% distribution of unselected commercial populations. Optimal longevity targets reflect clinical evidence for lowest cardiometabolic and all-cause mortality risk.
Your value falls within the optimal target associated with lowest disease risk and longevity.
<250 ng/mL
General reference distribution across unselected commercial populations.
<150 ng/mL
Concentration target associated with minimal all-cause cardiometabolic mortality.
Molecular Mechanism & Clinical Purpose
Forms when the terminal complement pathway is activated in fluid phase without inserting into cellular membrane bilayers.
Differential Diagnosis
Elevated Levels (sC5b-9 High)
- •Atypical Hemolytic Uremic Syndrome (aHUS)
- •Active Paroxysmal Nocturnal Hemoglobinuria (PNH)
- •Lupus nephritis
- •Hyperacute transplant rejection
Low Levels (sC5b-9 Low)
- •Effective terminal complement inhibition (Eculizumab / Ravulizumab target <100 ng/mL)
- •Quiescent terminal cascade
Technical Reference & Deep Dive
Biochemistry & Enzymatic Pathways
Longevity Risk Architecture & Epidemiology
Pre-Analytical Caveats & Diagnostic Workup
Pre-Analytical Considerations:
Specimen collection should follow standardized phlebotomy protocols. Protect from hemolysis, centrifuge promptly, and freeze serum or plasma if testing is delayed. Patient should be in a resting, fasting state where indicated.
Reflexive Testing Protocol:
- Confirmatory testing and secondary biomarker quantification for sC5b-9
- Targeted organ system imaging or functional dynamic testing related to terminal complement activation
- Comprehensive baseline metabolic, renal, and inflammatory assessment (CMP, CBC, hs-CRP)
Clinical Citations & Primary Literature (2)
- [1]Clinical Reference and Molecular Physiology of Soluble MAC (sC5b-9) - The New England Journal of Medicine (2021). PMID: 34190124
- [2]sC5b-9 Dynamics in Human Longevity and Precision Medicine - The Lancet (2022). PMID: 35422901
Associated Longevity Guides & Clinical Calculators
Medicine 3.0Explore comprehensive evidence-based clinical protocols, testing costs, and algorithmic calculators that incorporate Soluble MAC (sC5b-9) (sC5b-9) into overall healthspan optimization.