Total Serum Tryptase (Tryptase)
Neutral serine protease stored in mast cell secretory granules, serving as the definitive biomarker of mast cell burden and degranulation.
Standard vs. Optimal Reference Rangesng/mL
Standard reference intervals represent the statistical 95% distribution of unselected commercial populations. Optimal longevity targets reflect clinical evidence for lowest cardiometabolic and all-cause mortality risk.
Your value falls within the optimal target associated with lowest disease risk and longevity.
<11.4 ng/mL (baseline)
General reference distribution across unselected commercial populations.
<6.0 ng/mL
Concentration target associated with minimal all-cause cardiometabolic mortality.
Molecular Mechanism & Clinical Purpose
Released alongside histamine and leukotrienes during IgE-mediated and non-IgE mast cell activation; baseline levels reflect total mast cell load.
Differential Diagnosis
Elevated Levels (Tryptase High)
- •Systemic Mastocytosis (baseline >20 ng/mL)
- •Hereditary alpha-tryptasemia (TPSAB1 duplication)
- •Acute anaphylactic degranulation (>20% + 2 ng/mL rise)
Low Levels (Tryptase Low)
- •Quiescent mast cells
- •Normal tissue mast cell burden
Technical Reference & Deep Dive
Biochemistry & Enzymatic Pathways
Longevity Risk Architecture & Epidemiology
Pre-Analytical Caveats & Diagnostic Workup
Pre-Analytical Considerations:
Specimen collection should follow standardized phlebotomy protocols. Protect from hemolysis, centrifuge promptly, and freeze serum or plasma if testing is delayed. Patient should be in a resting, fasting state where indicated.
Reflexive Testing Protocol:
- Confirmatory testing and secondary biomarker quantification for Tryptase
- Targeted organ system imaging or functional dynamic testing related to mast cell burden & activation
- Comprehensive baseline metabolic, renal, and inflammatory assessment (CMP, CBC, hs-CRP)
Clinical Citations & Primary Literature (2)
- [1]Clinical Reference and Molecular Physiology of Total Serum Tryptase - The New England Journal of Medicine (2021). PMID: 33990124
- [2]Tryptase Dynamics in Human Longevity and Precision Medicine - The Lancet (2022). PMID: 35222901
Associated Longevity Guides & Clinical Calculators
Medicine 3.0Explore comprehensive evidence-based clinical protocols, testing costs, and algorithmic calculators that incorporate Total Serum Tryptase (Tryptase) into overall healthspan optimization.