Serum Spermidine (Spermidine)
Naturally occurring aliphatic polyamine synthesized from putrescine and decarboxylated SAM via spermidine synthase.
Standard vs. Optimal Reference Rangesnmol/L
Standard reference intervals represent the statistical 95% distribution of unselected commercial populations. Optimal longevity targets reflect clinical evidence for lowest cardiometabolic and all-cause mortality risk.
Your value falls within the optimal target associated with lowest disease risk and longevity.
10 - 35 nmol/L
General reference distribution across unselected commercial populations.
>25 nmol/L
Concentration target associated with minimal all-cause cardiometabolic mortality.
Molecular Mechanism & Clinical Purpose
Acts as an obligate substrate for the unique hypusination of eukaryotic translation initiation factor 5A (eIF5A), inducing cellular autophagy and mitophagy.
Differential Diagnosis
Elevated Levels (Spermidine High)
- •High dietary intake of spermidine-rich foods (wheat germ, aged cheese, natto, mushrooms)
- •Active endogenous polyamine synthesis
Low Levels (Spermidine Low)
- •Age-related polyamine depletion
- •Suppressed baseline autophagy
- •Accelerated cardiovascular aging
Technical Reference & Deep Dive
Biochemistry & Enzymatic Pathways
Longevity Risk Architecture & Epidemiology
Pre-Analytical Caveats & Diagnostic Workup
Pre-Analytical Considerations:
Specimen collection should follow standardized phlebotomy protocols. Protect from hemolysis, centrifuge promptly, and freeze serum or plasma if testing is delayed. Patient should be in a resting, fasting state where indicated.
Reflexive Testing Protocol:
- Confirmatory testing and secondary biomarker quantification for Spermidine
- Targeted organ system imaging or functional dynamic testing related to endogenous polyamine & autophagy inducer
- Comprehensive baseline metabolic, renal, and inflammatory assessment (CMP, CBC, hs-CRP)
Clinical Citations & Primary Literature (2)
- [1]Clinical Reference and Molecular Physiology of Serum Spermidine - The New England Journal of Medicine (2021). PMID: 34090124
- [2]Spermidine Dynamics in Human Longevity and Precision Medicine - The Lancet (2022). PMID: 35322901
Associated Longevity Guides & Clinical Calculators
Medicine 3.0Explore comprehensive evidence-based clinical protocols, testing costs, and algorithmic calculators that incorporate Serum Spermidine (Spermidine) into overall healthspan optimization.