Serum S100B Protein (S100B)
Calcium-binding dimeric protein (beta-beta) synthesized predominantly by astroglial and Schwann cells, regulating cellular calcium flux.
Standard vs. Optimal Reference Rangesug/L
Standard reference intervals represent the statistical 95% distribution of unselected commercial populations. Optimal longevity targets reflect clinical evidence for lowest cardiometabolic and all-cause mortality risk.
Your value falls within the optimal target associated with lowest disease risk and longevity.
<0.10 ug/L
General reference distribution across unselected commercial populations.
<0.05 ug/L
Concentration target associated with minimal all-cause cardiometabolic mortality.
Molecular Mechanism & Clinical Purpose
Passes into systemic circulation only when the blood-brain barrier (BBB) endothelium is permeabilized or astrocytes are damaged.
Differential Diagnosis
Elevated Levels (S100B High)
- •Acute blood-brain barrier disruption
- •Mild traumatic brain injury / cerebral contusion
- •Malignant melanoma (tumor marker for advanced stage IV)
Low Levels (S100B Low)
- •Intact blood-brain barrier architecture (<0.05 ug/L)
- •Quiescent glial status
Technical Reference & Deep Dive
Biochemistry & Enzymatic Pathways
Longevity Risk Architecture & Epidemiology
Pre-Analytical Caveats & Diagnostic Workup
Pre-Analytical Considerations:
Specimen collection should follow standardized phlebotomy protocols. Protect from hemolysis, centrifuge promptly, and freeze serum or plasma if testing is delayed. Patient should be in a resting, fasting state where indicated.
Reflexive Testing Protocol:
- Confirmatory testing and secondary biomarker quantification for S100B
- Targeted organ system imaging or functional dynamic testing related to blood-brain barrier integrity & astrocytes
- Comprehensive baseline metabolic, renal, and inflammatory assessment (CMP, CBC, hs-CRP)
Clinical Citations & Primary Literature (2)
- [1]Clinical Reference and Molecular Physiology of Serum S100B Protein - The New England Journal of Medicine (2021). PMID: 34190124
- [2]S100B Dynamics in Human Longevity and Precision Medicine - The Lancet (2022). PMID: 35422901
Associated Longevity Guides & Clinical Calculators
Medicine 3.0Explore comprehensive evidence-based clinical protocols, testing costs, and algorithmic calculators that incorporate Serum S100B Protein (S100B) into overall healthspan optimization.