Serum Oleic Acid (Oleic Acid)
18-carbon cis-monounsaturated fatty acid (18:1 cis-9), the predominant fatty acid in extra virgin olive oil and human cell membranes.
Standard vs. Optimal Reference Ranges%
Standard reference intervals represent the statistical 95% distribution of unselected commercial populations. Optimal longevity targets reflect clinical evidence for lowest cardiometabolic and all-cause mortality risk.
Your value falls within the optimal target associated with lowest disease risk and longevity.
18.0 - 28.0% total fatty acids
General reference distribution across unselected commercial populations.
20.0 - 26.0%
Concentration target associated with minimal all-cause cardiometabolic mortality.
Molecular Mechanism & Clinical Purpose
Resistant to free radical-mediated lipid peroxidation compared to polyunsaturated fats; activates SIRT1 and improves membrane fluidity.
Differential Diagnosis
Elevated Levels (Oleic Acid High)
- •High extra virgin olive oil and avocado dietary intake
Low Levels (Oleic Acid Low)
- •Low dietary monounsaturated fat intake
Technical Reference & Deep Dive
Biochemistry & Enzymatic Pathways
Longevity Risk Architecture & Epidemiology
Pre-Analytical Caveats & Diagnostic Workup
Pre-Analytical Considerations:
Specimen collection should follow standardized phlebotomy protocols. Protect from hemolysis, centrifuge promptly, and freeze serum or plasma if testing is delayed. Patient should be in a resting, fasting state where indicated.
Reflexive Testing Protocol:
- Confirmatory testing and secondary biomarker quantification for Oleic Acid
- Targeted organ system imaging or functional dynamic testing related to monounsaturated fatty acid homeostasis
- Comprehensive baseline metabolic, renal, and inflammatory assessment (CMP, CBC, hs-CRP)
Clinical Citations & Primary Literature (2)
- [1]Clinical Reference and Molecular Physiology of Serum Oleic Acid - The New England Journal of Medicine (2021). PMID: 34090124
- [2]Oleic Acid Dynamics in Human Longevity and Precision Medicine - The Lancet (2022). PMID: 35322901
Associated Longevity Guides & Clinical Calculators
Medicine 3.0Explore comprehensive evidence-based clinical protocols, testing costs, and algorithmic calculators that incorporate Serum Oleic Acid (Oleic Acid) into overall healthspan optimization.