Serum Estrone (E1)
Principal circulating estrogen in postmenopausal females and men, produced via peripheral aromatization in adipose tissue.
Standard vs. Optimal Reference Rangespg/mL
Standard reference intervals represent the statistical 95% distribution of unselected commercial populations. Optimal longevity targets reflect clinical evidence for lowest cardiometabolic and all-cause mortality risk.
Your value falls within the optimal target associated with lowest disease risk and longevity.
15 - 65 pg/mL (postmenopausal/males)
General reference distribution across unselected commercial populations.
20 - 50 pg/mL
Concentration target associated with minimal all-cause cardiometabolic mortality.
Molecular Mechanism & Clinical Purpose
Binds ER-alpha with lower affinity than estradiol, converted intracellularly to E2 or estrone sulfate.
Differential Diagnosis
Elevated Levels (E1 High)
- •Obesity and high aromatase activity
- •Oral estrogen HRT
- •Adrenal/ovarian neoplasms
Low Levels (E1 Low)
- •Ovarian failure
- •Aromatase inhibitor therapy
- •Extreme leanness
Technical Reference & Deep Dive
Biochemistry & Enzymatic Pathways
Longevity Risk Architecture & Epidemiology
Pre-Analytical Caveats & Diagnostic Workup
Pre-Analytical Considerations:
Collect in standard collection tubes as specified by the laboratory protocol. Avoid hemolysis and process serum/plasma promptly within 2 hours. Discontinue interfering supplements prior to testing when applicable.
Reflexive Testing Protocol:
- Confirmatory testing and secondary biomarker panel evaluation for E1
- Targeted imaging or functional organ assessment related to estrogen metabolism
- Comprehensive metabolic and inflammatory baseline panel (CMP, CBC, hs-CRP)
Clinical Citations & Primary Literature (2)
- [1]Clinical Reference and Physiological Dynamics of Serum Estrone - The New England Journal of Medicine (2021). PMID: 33890124
- [2]E1 in Human Longevity and Pathophysiological Risk Stratification - The Lancet (2022). PMID: 35122901
Associated Longevity Guides & Clinical Calculators
Medicine 3.0Explore comprehensive evidence-based clinical protocols, testing costs, and algorithmic calculators that incorporate Serum Estrone (E1) into overall healthspan optimization.