Total Serum Bile Acids (SBA)
Endogenous amphipathic steroids synthesized from cholesterol in liver and conjugated to glycine/taurine for biliary lipid digestion.
Standard vs. Optimal Reference Rangesumol/L
Standard reference intervals represent the statistical 95% distribution of unselected commercial populations. Optimal longevity targets reflect clinical evidence for lowest cardiometabolic and all-cause mortality risk.
Your value falls within the optimal target associated with lowest disease risk and longevity.
<10.0 umol/L (fasting)
General reference distribution across unselected commercial populations.
<6.0 umol/L
Concentration target associated with minimal all-cause cardiometabolic mortality.
Molecular Mechanism & Clinical Purpose
Undergoes active ileal reabsorption (95%) and portal extraction; elevation indicates impaired canalicular excretion or portosystemic shunting.
Differential Diagnosis
Elevated Levels (SBA High)
- •Intrahepatic cholestasis of pregnancy (ICP, >10 umol/L triggers fetal risk)
- •Portosystemic shunts and cirrhosis
- •Biliary obstruction
Low Levels (SBA Low)
- •Terminal ileal resection (bile acid malabsorption)
- •Optimal enterohepatic clearance
Technical Reference & Deep Dive
Biochemistry & Enzymatic Pathways
Longevity Risk Architecture & Epidemiology
Pre-Analytical Caveats & Diagnostic Workup
Pre-Analytical Considerations:
Collect in standard collection tubes as specified by the laboratory protocol. Avoid hemolysis and process serum/plasma promptly within 2 hours. Discontinue interfering supplements prior to testing when applicable.
Reflexive Testing Protocol:
- Confirmatory testing and secondary biomarker panel evaluation for SBA
- Targeted imaging or functional organ assessment related to biliary clearance & enterohepatic flux
- Comprehensive metabolic and inflammatory baseline panel (CMP, CBC, hs-CRP)
Clinical Citations & Primary Literature (2)
- [1]Clinical Reference and Physiological Dynamics of Total Serum Bile Acids - The New England Journal of Medicine (2021). PMID: 33890124
- [2]SBA in Human Longevity and Pathophysiological Risk Stratification - The Lancet (2022). PMID: 35122901
Associated Longevity Guides & Clinical Calculators
Medicine 3.0Explore comprehensive evidence-based clinical protocols, testing costs, and algorithmic calculators that incorporate Total Serum Bile Acids (SBA) into overall healthspan optimization.