Serum S-Adenosylmethionine (SAM)
High-energy sulfonium compound synthesized from methionine and ATP by methionine adenosyltransferase (MAT).
Standard vs. Optimal Reference Rangesnmol/L
Standard reference intervals represent the statistical 95% distribution of unselected commercial populations. Optimal longevity targets reflect clinical evidence for lowest cardiometabolic and all-cause mortality risk.
Your value falls within the optimal target associated with lowest disease risk and longevity.
80 - 140 nmol/L
General reference distribution across unselected commercial populations.
95 - 130 nmol/L
Concentration target associated with minimal all-cause cardiometabolic mortality.
Molecular Mechanism & Clinical Purpose
Donates methyl groups (-CH3) to DNA methyltransferases (DNMT), histone methyltransferases, COMT, and PEMT for phosphatidylcholine.
Differential Diagnosis
Elevated Levels (SAM High)
- •High methyl donor sufficiency
- •Exogenous SAMe supplementation
Low Levels (SAM Low)
- •Impaired one-carbon methylation capacity
- •Methionine restriction or MAT deficiency
- •Severe liver failure
Technical Reference & Deep Dive
Biochemistry & Enzymatic Pathways
Longevity Risk Architecture & Epidemiology
Pre-Analytical Caveats & Diagnostic Workup
Pre-Analytical Considerations:
Specimen collection should follow standardized phlebotomy protocols. Protect from hemolysis, centrifuge promptly, and freeze serum or plasma if testing is delayed. Patient should be in a resting, fasting state where indicated.
Reflexive Testing Protocol:
- Confirmatory testing and secondary biomarker quantification for SAM
- Targeted organ system imaging or functional dynamic testing related to universal cellular methyl donor
- Comprehensive baseline metabolic, renal, and inflammatory assessment (CMP, CBC, hs-CRP)
Clinical Citations & Primary Literature (2)
- [1]Clinical Reference and Molecular Physiology of Serum S-Adenosylmethionine - The New England Journal of Medicine (2021). PMID: 33990124
- [2]SAM Dynamics in Human Longevity and Precision Medicine - The Lancet (2022). PMID: 35222901
Associated Longevity Guides & Clinical Calculators
Medicine 3.0Explore comprehensive evidence-based clinical protocols, testing costs, and algorithmic calculators that incorporate Serum S-Adenosylmethionine (SAM) into overall healthspan optimization.