Plasma Somatostatin (SS / SRIF)
14-amino-acid cyclic peptide synthesized by hypothalamic periventricular neurons and pancreatic islet delta-cells.
Standard vs. Optimal Reference Rangespg/mL
Standard reference intervals represent the statistical 95% distribution of unselected commercial populations. Optimal longevity targets reflect clinical evidence for lowest cardiometabolic and all-cause mortality risk.
Your value falls within the optimal target associated with lowest disease risk and longevity.
<25.0 pg/mL
General reference distribution across unselected commercial populations.
<15.0 pg/mL
Concentration target associated with minimal all-cause cardiometabolic mortality.
Molecular Mechanism & Clinical Purpose
Binds SSTR1-5 receptors coupled to inhibitory G-proteins (Gi), suppressing GH, TSH, insulin, glucagon, gastrin, secretin, and gallbladder contraction.
Differential Diagnosis
Elevated Levels (SS / SRIF High)
- •Somatostatinoma neuroendocrine tumor (inhibitory triad: diabetes, cholelithiasis, steatorrhea)
- •Medullary thyroid carcinoma
Low Levels (SS / SRIF Low)
- •Normal resting baseline
- •Quiescent neuroendocrine state
Technical Reference & Deep Dive
Biochemistry & Enzymatic Pathways
Longevity Risk Architecture & Epidemiology
Pre-Analytical Caveats & Diagnostic Workup
Pre-Analytical Considerations:
Specimen collection should follow standardized phlebotomy protocols. Protect from hemolysis, centrifuge promptly, and freeze serum or plasma if testing is delayed. Patient should be in a resting, fasting state where indicated.
Reflexive Testing Protocol:
- Confirmatory testing and secondary biomarker quantification for SS / SRIF
- Targeted organ system imaging or functional dynamic testing related to universal inhibitory neurohormone
- Comprehensive baseline metabolic, renal, and inflammatory assessment (CMP, CBC, hs-CRP)
Clinical Citations & Primary Literature (2)
- [1]Clinical Reference and Molecular Physiology of Plasma Somatostatin - The New England Journal of Medicine (2021). PMID: 34190124
- [2]SS / SRIF Dynamics in Human Longevity and Precision Medicine - The Lancet (2022). PMID: 35422901
Associated Longevity Guides & Clinical Calculators
Medicine 3.0Explore comprehensive evidence-based clinical protocols, testing costs, and algorithmic calculators that incorporate Plasma Somatostatin (SS / SRIF) into overall healthspan optimization.