Plasma Phosphorylated-Tau 217 (p-Tau217)
Tau protein specifically phosphorylated at threonine 217, exhibiting near-perfect concordance (>95% AUC) with brain amyloid PET imaging.
Standard vs. Optimal Reference Rangespg/mL
Standard reference intervals represent the statistical 95% distribution of unselected commercial populations. Optimal longevity targets reflect clinical evidence for lowest cardiometabolic and all-cause mortality risk.
Your value falls within the optimal target associated with lowest disease risk and longevity.
<0.30 pg/mL (or <4.0% p-Tau217 / t-Tau ratio)
General reference distribution across unselected commercial populations.
<0.15 pg/mL
Concentration target associated with minimal all-cause cardiometabolic mortality.
Molecular Mechanism & Clinical Purpose
Hyperphosphorylated and secreted by neurons in direct stoichiometric proportion to brain amyloid-beta burden and tau tangle spread.
Differential Diagnosis
Elevated Levels (p-Tau217 High)
- •Cortical amyloid-beta plaque deposition and active Alzheimer pathology
- •High risk of rapid cognitive conversion
Low Levels (p-Tau217 Low)
- •Negative amyloid PET status
- •Normal healthy cognitive trajectory
Technical Reference & Deep Dive
Biochemistry & Enzymatic Pathways
Longevity Risk Architecture & Epidemiology
Pre-Analytical Caveats & Diagnostic Workup
Pre-Analytical Considerations:
Specimen collection should follow standardized phlebotomy protocols. Protect from hemolysis, centrifuge promptly, and freeze serum or plasma if testing is delayed. Patient should be in a resting, fasting state where indicated.
Reflexive Testing Protocol:
- Confirmatory testing and secondary biomarker quantification for p-Tau217
- Targeted organ system imaging or functional dynamic testing related to ultra-accurate alzheimer pathology
- Comprehensive baseline metabolic, renal, and inflammatory assessment (CMP, CBC, hs-CRP)
Clinical Citations & Primary Literature (2)
- [1]Clinical Reference and Molecular Physiology of Plasma Phosphorylated-Tau 217 - The New England Journal of Medicine (2021). PMID: 34190124
- [2]p-Tau217 Dynamics in Human Longevity and Precision Medicine - The Lancet (2022). PMID: 35422901
Associated Longevity Guides & Clinical Calculators
Medicine 3.0Explore comprehensive evidence-based clinical protocols, testing costs, and algorithmic calculators that incorporate Plasma Phosphorylated-Tau 217 (p-Tau217) into overall healthspan optimization.