Plasma Norepinephrine (Noradrenaline) (NE)
Principal neurotransmitter of postganglionic sympathetic neurons and circulating vasoconstrictor hormone.
Standard vs. Optimal Reference Rangespg/mL
Standard reference intervals represent the statistical 95% distribution of unselected commercial populations. Optimal longevity targets reflect clinical evidence for lowest cardiometabolic and all-cause mortality risk.
Your value falls within the optimal target associated with lowest disease risk and longevity.
70 - 750 pg/mL (resting supine)
General reference distribution across unselected commercial populations.
150 - 450 pg/mL
Concentration target associated with minimal all-cause cardiometabolic mortality.
Molecular Mechanism & Clinical Purpose
Binds alpha-1 and beta-1 adrenergic receptors, inducing peripheral vasoconstriction, elevated total peripheral resistance, and inotropy.
Differential Diagnosis
Elevated Levels (NE High)
- •Postural Orthostatic Tachycardia Syndrome (POTS)
- •Chronic essential hypertension
- •Pheochromocytoma/Paraganglioma
- •Congestive heart failure
Low Levels (NE Low)
- •Pure autonomic failure
- •Multiple system atrophy
- •Orthostatic hypotension
Technical Reference & Deep Dive
Biochemistry & Enzymatic Pathways
Longevity Risk Architecture & Epidemiology
Pre-Analytical Caveats & Diagnostic Workup
Pre-Analytical Considerations:
Collect in standard collection tubes as specified by the laboratory protocol. Avoid hemolysis and process serum/plasma promptly within 2 hours. Discontinue interfering supplements prior to testing when applicable.
Reflexive Testing Protocol:
- Confirmatory testing and secondary biomarker panel evaluation for NE
- Targeted imaging or functional organ assessment related to sympathetic neurotransmission
- Comprehensive metabolic and inflammatory baseline panel (CMP, CBC, hs-CRP)
Clinical Citations & Primary Literature (2)
- [1]Clinical Reference and Physiological Dynamics of Plasma Norepinephrine (Noradrenaline) - The New England Journal of Medicine (2021). PMID: 33890124
- [2]NE in Human Longevity and Pathophysiological Risk Stratification - The Lancet (2022). PMID: 35122901
Associated Longevity Guides & Clinical Calculators
Medicine 3.0Explore comprehensive evidence-based clinical protocols, testing costs, and algorithmic calculators that incorporate Plasma Norepinephrine (Noradrenaline) (NE) into overall healthspan optimization.