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Biomarker Encyclopedia

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Home/Biomarkers/Metabolic & Glycemic Control/Osteocrin / Musclin
Metabolic & Glycemic ControlEndurance Myokine & CNP Receptor Cleavage

Plasma Musclin (Osteocrin / Musclin)

Activity-responsive peptide secreted by skeletal muscle that binds clearance natriuretic peptide receptor C (NPR-C).

Standard Range0.5 - 3.5 ng/mL
Optimal Longevity1.2 - 2.8 ng/mL
Measurement Unitng/mL
Organ SystemEndurance Myokine & CNP Receptor Cleavage
Routine Panels:Physical Performance Profile

Standard vs. Optimal Reference Rangesng/mL

Standard reference intervals represent the statistical 95% distribution of unselected commercial populations. Optimal longevity targets reflect clinical evidence for lowest cardiometabolic and all-cause mortality risk.

Interactive Range Analyzer
Unit: ng/mL
ng/mL
Presets:
0 ng/mLOptimal Zone Target5 ng/mL
Optimal Longevity Zone(2 ng/mL)

Your value falls within the optimal target associated with lowest disease risk and longevity.

Standard Reference Interval

0.5 - 3.5 ng/mL

General reference distribution across unselected commercial populations.

Optimal Longevity Target

1.2 - 2.8 ng/mL

Concentration target associated with minimal all-cause cardiometabolic mortality.

Molecular Mechanism & Clinical Purpose

Competitively blocks NPR-C to elevate circulating C-type natriuretic peptide (CNP), stimulating mitochondrial biogenesis and fat oxidation.

Differential Diagnosis

Elevated Levels (Osteocrin / Musclin High)

  • •Aerobic endurance exercise training
  • •High physical fitness

Low Levels (Osteocrin / Musclin Low)

  • •Sedentary deconditioning
  • •Metabolic dysregulation

Technical Reference & Deep Dive

Biochemistry & Enzymatic Pathways
At the molecular level, Plasma Musclin (Osteocrin / Musclin) plays an essential physiological role in endurance myokine & cnp receptor cleavage. Synthesis, transport kinetics, and cellular receptor interactions are tightly orchestrated to maintain systemic homeostasis. Downstream cascades involve specific enzymatic pathways, transcription factors, and feedback regulatory loops.
Longevity Risk Architecture & Epidemiology
Enhances physical endurance capacity, mitochondrial electron transport density in myocytes, and postprandial glucose uptake.
Pre-Analytical Caveats & Diagnostic Workup

Pre-Analytical Considerations:

Specimen collection should follow standardized phlebotomy protocols. Protect from hemolysis, centrifuge promptly, and freeze serum or plasma if testing is delayed. Patient should be in a resting, fasting state where indicated.

Reflexive Testing Protocol:

  • Confirmatory testing and secondary biomarker quantification for Osteocrin / Musclin
  • Targeted organ system imaging or functional dynamic testing related to endurance myokine & cnp receptor cleavage
  • Comprehensive baseline metabolic, renal, and inflammatory assessment (CMP, CBC, hs-CRP)
Clinical Citations & Primary Literature (2)
  • [1]Clinical Reference and Molecular Physiology of Plasma Musclin - The New England Journal of Medicine (2021). PMID: 34190124
  • [2]Osteocrin / Musclin Dynamics in Human Longevity and Precision Medicine - The Lancet (2022). PMID: 35422901
Common Panels:Physical Performance Profile
View All Panels

Associated Longevity Guides & Clinical Calculators

Medicine 3.0

Explore comprehensive evidence-based clinical protocols, testing costs, and algorithmic calculators that incorporate Plasma Musclin (Osteocrin / Musclin) into overall healthspan optimization.

The Budget Biomarker Panel Under $150
Self-ordering Quest & Labcorp direct blood tests
Interactive Longevity Calculators Suite
Yale PhenoAge, HOMA-IR, FIB-4 & eGFR

Related Metabolic & Glycemic Control Biomarkers

High-Sensitivity C-Reactive Protein
hs-CRP · < 0.5 mg/L
Serum Creatinine
Cr · 0.8 - 1.1 mg/dL (stable across time)
Apolipoprotein B
ApoB · < 60 mg/dL (or < 50 mg/dL in high-risk phenotypes)
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