Plasma Musclin (Osteocrin / Musclin)
Activity-responsive peptide secreted by skeletal muscle that binds clearance natriuretic peptide receptor C (NPR-C).
Standard vs. Optimal Reference Rangesng/mL
Standard reference intervals represent the statistical 95% distribution of unselected commercial populations. Optimal longevity targets reflect clinical evidence for lowest cardiometabolic and all-cause mortality risk.
Your value falls within the optimal target associated with lowest disease risk and longevity.
0.5 - 3.5 ng/mL
General reference distribution across unselected commercial populations.
1.2 - 2.8 ng/mL
Concentration target associated with minimal all-cause cardiometabolic mortality.
Molecular Mechanism & Clinical Purpose
Competitively blocks NPR-C to elevate circulating C-type natriuretic peptide (CNP), stimulating mitochondrial biogenesis and fat oxidation.
Differential Diagnosis
Elevated Levels (Osteocrin / Musclin High)
- •Aerobic endurance exercise training
- •High physical fitness
Low Levels (Osteocrin / Musclin Low)
- •Sedentary deconditioning
- •Metabolic dysregulation
Technical Reference & Deep Dive
Biochemistry & Enzymatic Pathways
Longevity Risk Architecture & Epidemiology
Pre-Analytical Caveats & Diagnostic Workup
Pre-Analytical Considerations:
Specimen collection should follow standardized phlebotomy protocols. Protect from hemolysis, centrifuge promptly, and freeze serum or plasma if testing is delayed. Patient should be in a resting, fasting state where indicated.
Reflexive Testing Protocol:
- Confirmatory testing and secondary biomarker quantification for Osteocrin / Musclin
- Targeted organ system imaging or functional dynamic testing related to endurance myokine & cnp receptor cleavage
- Comprehensive baseline metabolic, renal, and inflammatory assessment (CMP, CBC, hs-CRP)
Clinical Citations & Primary Literature (2)
- [1]Clinical Reference and Molecular Physiology of Plasma Musclin - The New England Journal of Medicine (2021). PMID: 34190124
- [2]Osteocrin / Musclin Dynamics in Human Longevity and Precision Medicine - The Lancet (2022). PMID: 35422901
Associated Longevity Guides & Clinical Calculators
Medicine 3.0Explore comprehensive evidence-based clinical protocols, testing costs, and algorithmic calculators that incorporate Plasma Musclin (Osteocrin / Musclin) into overall healthspan optimization.