Plasma Cystathionine (Cystathionine)
Thioether intermediate synthesized from homocysteine and serine by vitamin B6-dependent cystathionine beta-synthase (CBS).
Standard vs. Optimal Reference Rangesnmol/L
Standard reference intervals represent the statistical 95% distribution of unselected commercial populations. Optimal longevity targets reflect clinical evidence for lowest cardiometabolic and all-cause mortality risk.
Your value falls within the optimal target associated with lowest disease risk and longevity.
40 - 250 nmol/L
General reference distribution across unselected commercial populations.
60 - 180 nmol/L
Concentration target associated with minimal all-cause cardiometabolic mortality.
Molecular Mechanism & Clinical Purpose
Cleaved by cystathionine gamma-lyase (CTH / CSE) into cysteine and alpha-ketobutyrate; accumulates when B6 is deficient or renal clearance is impaired.
Differential Diagnosis
Elevated Levels (Cystathionine High)
- •Vitamin B6 (Pyridoxal-5-Phosphate) functional deficiency
- •Chronic kidney disease (decreased renal clearance)
- •Cystathioninuria (CTH deficiency)
Low Levels (Cystathionine Low)
- •Optimal transsulfuration flux to cysteine and glutathione
- •Normal B6 sufficiency
Technical Reference & Deep Dive
Biochemistry & Enzymatic Pathways
Longevity Risk Architecture & Epidemiology
Pre-Analytical Caveats & Diagnostic Workup
Pre-Analytical Considerations:
Specimen collection should follow standardized phlebotomy protocols. Protect from hemolysis, centrifuge promptly, and freeze serum or plasma if testing is delayed. Patient should be in a resting, fasting state where indicated.
Reflexive Testing Protocol:
- Confirmatory testing and secondary biomarker quantification for Cystathionine
- Targeted organ system imaging or functional dynamic testing related to transsulfuration intermediate
- Comprehensive baseline metabolic, renal, and inflammatory assessment (CMP, CBC, hs-CRP)
Clinical Citations & Primary Literature (2)
- [1]Clinical Reference and Molecular Physiology of Plasma Cystathionine - The New England Journal of Medicine (2021). PMID: 34190124
- [2]Cystathionine Dynamics in Human Longevity and Precision Medicine - The Lancet (2022). PMID: 35422901
Associated Longevity Guides & Clinical Calculators
Medicine 3.0Explore comprehensive evidence-based clinical protocols, testing costs, and algorithmic calculators that incorporate Plasma Cystathionine (Cystathionine) into overall healthspan optimization.