Plasma Octanoylcarnitine (C8) (C8 Acylcarnitine)
Medium-chain acylcarnitine intermediate that accumulates when medium-chain acyl-CoA dehydrogenase (MCAD) is deficient.
Standard vs. Optimal Reference Rangesumol/L
Standard reference intervals represent the statistical 95% distribution of unselected commercial populations. Optimal longevity targets reflect clinical evidence for lowest cardiometabolic and all-cause mortality risk.
Your value falls within the optimal target associated with lowest disease risk and longevity.
<0.30 umol/L
General reference distribution across unselected commercial populations.
<0.15 umol/L
Concentration target associated with minimal all-cause cardiometabolic mortality.
Molecular Mechanism & Clinical Purpose
Formed by mitochondrial carnitine octanoyltransferase esterifying accumulated octanoyl-CoA, which is released into circulation.
Differential Diagnosis
Elevated Levels (C8 Acylcarnitine High)
- •Medium-Chain Acyl-CoA Dehydrogenase (MCAD) Deficiency
- •Medium-chain fatty acid oxidation defects
Low Levels (C8 Acylcarnitine Low)
- •Normal mitochondrial beta-oxidation flux
- •Optimal fatty acid energy generation
Technical Reference & Deep Dive
Biochemistry & Enzymatic Pathways
Longevity Risk Architecture & Epidemiology
Pre-Analytical Caveats & Diagnostic Workup
Pre-Analytical Considerations:
Specimen collection should follow standardized phlebotomy protocols. Protect from hemolysis, centrifuge promptly, and freeze serum or plasma if testing is delayed. Patient should be in a resting, fasting state where indicated.
Reflexive Testing Protocol:
- Confirmatory testing and secondary biomarker quantification for C8 Acylcarnitine
- Targeted organ system imaging or functional dynamic testing related to medium-chain fatty acid beta-oxidation
- Comprehensive baseline metabolic, renal, and inflammatory assessment (CMP, CBC, hs-CRP)
Clinical Citations & Primary Literature (2)
- [1]Clinical Reference and Molecular Physiology of Plasma Octanoylcarnitine (C8) - The New England Journal of Medicine (2021). PMID: 34090124
- [2]C8 Acylcarnitine Dynamics in Human Longevity and Precision Medicine - The Lancet (2022). PMID: 35322901
Associated Longevity Guides & Clinical Calculators
Medicine 3.0Explore comprehensive evidence-based clinical protocols, testing costs, and algorithmic calculators that incorporate Plasma Octanoylcarnitine (C8) (C8 Acylcarnitine) into overall healthspan optimization.