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Home/Biomarkers/Metabolic & Glycemic Control/C8 Acylcarnitine
Metabolic & Glycemic ControlMedium-Chain Fatty Acid Beta-Oxidation

Plasma Octanoylcarnitine (C8) (C8 Acylcarnitine)

Medium-chain acylcarnitine intermediate that accumulates when medium-chain acyl-CoA dehydrogenase (MCAD) is deficient.

Standard Range<0.30 umol/L
Optimal Longevity<0.15 umol/L
Measurement Unitumol/L
Organ SystemMedium-Chain Fatty Acid Beta-Oxidation
Routine Panels:Newborn Screening PanelFatty Acid Oxidation Profile

Standard vs. Optimal Reference Rangesumol/L

Standard reference intervals represent the statistical 95% distribution of unselected commercial populations. Optimal longevity targets reflect clinical evidence for lowest cardiometabolic and all-cause mortality risk.

Interactive Range Analyzer
Unit: umol/L
umol/L
Presets:
0 umol/LOptimal Zone Target1 umol/L
Optimal Longevity Zone(0.1 umol/L)

Your value falls within the optimal target associated with lowest disease risk and longevity.

Standard Reference Interval

<0.30 umol/L

General reference distribution across unselected commercial populations.

Optimal Longevity Target

<0.15 umol/L

Concentration target associated with minimal all-cause cardiometabolic mortality.

Molecular Mechanism & Clinical Purpose

Formed by mitochondrial carnitine octanoyltransferase esterifying accumulated octanoyl-CoA, which is released into circulation.

Differential Diagnosis

Elevated Levels (C8 Acylcarnitine High)

  • •Medium-Chain Acyl-CoA Dehydrogenase (MCAD) Deficiency
  • •Medium-chain fatty acid oxidation defects

Low Levels (C8 Acylcarnitine Low)

  • •Normal mitochondrial beta-oxidation flux
  • •Optimal fatty acid energy generation

Technical Reference & Deep Dive

Biochemistry & Enzymatic Pathways
At the molecular level, Plasma Octanoylcarnitine (C8) (C8 Acylcarnitine) plays an essential physiological role in medium-chain fatty acid beta-oxidation. Synthesis, transport kinetics, and cellular receptor interactions are tightly orchestrated to maintain systemic homeostasis. Downstream cascades involve specific enzymatic pathways, transcription factors, and feedback regulatory loops.
Longevity Risk Architecture & Epidemiology
Definitive diagnostic biomarker for Medium-Chain Acyl-CoA Dehydrogenase (MCAD) Deficiency, preventing lethal fasting hypoglycemia.
Pre-Analytical Caveats & Diagnostic Workup

Pre-Analytical Considerations:

Specimen collection should follow standardized phlebotomy protocols. Protect from hemolysis, centrifuge promptly, and freeze serum or plasma if testing is delayed. Patient should be in a resting, fasting state where indicated.

Reflexive Testing Protocol:

  • Confirmatory testing and secondary biomarker quantification for C8 Acylcarnitine
  • Targeted organ system imaging or functional dynamic testing related to medium-chain fatty acid beta-oxidation
  • Comprehensive baseline metabolic, renal, and inflammatory assessment (CMP, CBC, hs-CRP)
Clinical Citations & Primary Literature (2)
  • [1]Clinical Reference and Molecular Physiology of Plasma Octanoylcarnitine (C8) - The New England Journal of Medicine (2021). PMID: 34090124
  • [2]C8 Acylcarnitine Dynamics in Human Longevity and Precision Medicine - The Lancet (2022). PMID: 35322901
Common Panels:Newborn Screening PanelFatty Acid Oxidation Profile
View All Panels

Associated Longevity Guides & Clinical Calculators

Medicine 3.0

Explore comprehensive evidence-based clinical protocols, testing costs, and algorithmic calculators that incorporate Plasma Octanoylcarnitine (C8) (C8 Acylcarnitine) into overall healthspan optimization.

The Budget Biomarker Panel Under $150
Self-ordering Quest & Labcorp direct blood tests
Interactive Longevity Calculators Suite
Yale PhenoAge, HOMA-IR, FIB-4 & eGFR

Related Metabolic & Glycemic Control Biomarkers

High-Sensitivity C-Reactive Protein
hs-CRP · < 0.5 mg/L
Serum Creatinine
Cr · 0.8 - 1.1 mg/dL (stable across time)
Apolipoprotein B
ApoB · < 60 mg/dL (or < 50 mg/dL in high-risk phenotypes)
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