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Biomarker Encyclopedia

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Home/Biomarkers/Endocrinology & Hormones/iPTH
Endocrinology & HormonesCalcium-Phosphate Homeostasis

Intact Parathyroid Hormone (iPTH)

84-amino-acid peptide hormone secreted by parathyroid chief cells to elevate serum calcium and stimulate calcitriol synthesis.

Standard Range15 - 65 pg/mL
Optimal Longevity20 - 45 pg/mL
Measurement Unitpg/mL
Organ SystemCalcium-Phosphate Homeostasis
Routine Panels:Bone & Mineral MetabolismCalcium Regulation Profile

Standard vs. Optimal Reference Rangespg/mL

Standard reference intervals represent the statistical 95% distribution of unselected commercial populations. Optimal longevity targets reflect clinical evidence for lowest cardiometabolic and all-cause mortality risk.

Interactive Range Analyzer
Unit: pg/mL
pg/mL
Presets:
10 pg/mLOptimal Zone Target88 pg/mL
Optimal Longevity Zone(32.5 pg/mL)

Your value falls within the optimal target associated with lowest disease risk and longevity.

Standard Reference Interval

15 - 65 pg/mL

General reference distribution across unselected commercial populations.

Optimal Longevity Target

20 - 45 pg/mL

Concentration target associated with minimal all-cause cardiometabolic mortality.

Molecular Mechanism & Clinical Purpose

Binds PTH1R in bone and kidney, stimulating osteoclast bone resorption, calcium reabsorption, and renal 1alpha-hydroxylase.

Differential Diagnosis

Elevated Levels (iPTH High)

  • •Primary hyperparathyroidism (parathyroid adenoma)
  • •Secondary hyperparathyroidism (Vitamin D deficiency, CKD)
  • •Tertiary hyperparathyroidism

Low Levels (iPTH Low)

  • •Primary hypoparathyroidism (post-surgical)
  • •Hypercalcemia of malignancy (PTH-suppressed)
  • •Severe hypomagnesemia

Technical Reference & Deep Dive

Biochemistry & Enzymatic Pathways
At the molecular level, Intact Parathyroid Hormone (iPTH) is critically involved in calcium-phosphate homeostasis. Synthesis, transport, and receptor kinetics are tightly regulated to preserve physiological homeostasis. Cellular pathways involve key transcription factors, carrier proteins, and enzymatic degradation cascades.
Longevity Risk Architecture & Epidemiology
Master regulator of bone turnover, vascular calcification, and mineral metabolism in aging.
Pre-Analytical Caveats & Diagnostic Workup

Pre-Analytical Considerations:

Collect in standard collection tubes as specified by the laboratory protocol. Avoid hemolysis and process serum/plasma promptly within 2 hours. Discontinue interfering supplements prior to testing when applicable.

Reflexive Testing Protocol:

  • Confirmatory testing and secondary biomarker panel evaluation for iPTH
  • Targeted imaging or functional organ assessment related to calcium-phosphate homeostasis
  • Comprehensive metabolic and inflammatory baseline panel (CMP, CBC, hs-CRP)
Clinical Citations & Primary Literature (2)
  • [1]Clinical Reference and Physiological Dynamics of Intact Parathyroid Hormone - The New England Journal of Medicine (2021). PMID: 33890124
  • [2]iPTH in Human Longevity and Pathophysiological Risk Stratification - The Lancet (2022). PMID: 35122901
Common Panels:Bone & Mineral MetabolismCalcium Regulation Profile
View All Panels

Associated Longevity Guides & Clinical Calculators

Medicine 3.0

Explore comprehensive evidence-based clinical protocols, testing costs, and algorithmic calculators that incorporate Intact Parathyroid Hormone (iPTH) into overall healthspan optimization.

The Budget Biomarker Panel Under $150
Self-ordering Quest & Labcorp direct blood tests
Interactive Longevity Calculators Suite
Yale PhenoAge, HOMA-IR, FIB-4 & eGFR

Related Endocrinology & Hormones Biomarkers

High-Sensitivity C-Reactive Protein
hs-CRP · < 0.5 mg/L
Serum Creatinine
Cr · 0.8 - 1.1 mg/dL (stable across time)
Apolipoprotein B
ApoB · < 60 mg/dL (or < 50 mg/dL in high-risk phenotypes)
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