Mannose-Binding Lectin (MBL)
C-type pattern recognition lectin that recognizes repetitive mannose and N-acetylglucosamine patterns on microbial surfaces.
Standard vs. Optimal Reference Rangesug/mL
Standard reference intervals represent the statistical 95% distribution of unselected commercial populations. Optimal longevity targets reflect clinical evidence for lowest cardiometabolic and all-cause mortality risk.
Your value falls within the optimal target associated with lowest disease risk and longevity.
0.5 - 4.0 ug/mL (500 - 4000 ng/mL)
General reference distribution across unselected commercial populations.
>1.0 ug/mL
Concentration target associated with minimal all-cause cardiometabolic mortality.
Molecular Mechanism & Clinical Purpose
Recruits MASP-1 and MASP-2 to cleave C4 and C2, activating the lectin complement pathway without requiring antibodies.
Differential Diagnosis
Elevated Levels (MBL High)
- •Normal robust pattern recognition and lectin complement defense (>1.0 ug/mL)
Low Levels (MBL Low)
- •MBL deficiency (homozygous promoter/structural variants, high susceptibility to recurrent pyogenic infections)
- •Chemotherapy-induced neutropenic fever risk
Technical Reference & Deep Dive
Biochemistry & Enzymatic Pathways
Longevity Risk Architecture & Epidemiology
Pre-Analytical Caveats & Diagnostic Workup
Pre-Analytical Considerations:
Specimen collection should follow standardized phlebotomy protocols. Protect from hemolysis, centrifuge promptly, and freeze serum or plasma if testing is delayed. Patient should be in a resting, fasting state where indicated.
Reflexive Testing Protocol:
- Confirmatory testing and secondary biomarker quantification for MBL
- Targeted organ system imaging or functional dynamic testing related to lectin complement activation & innate defense
- Comprehensive baseline metabolic, renal, and inflammatory assessment (CMP, CBC, hs-CRP)
Clinical Citations & Primary Literature (2)
- [1]Clinical Reference and Molecular Physiology of Mannose-Binding Lectin - The New England Journal of Medicine (2021). PMID: 34190124
- [2]MBL Dynamics in Human Longevity and Precision Medicine - The Lancet (2022). PMID: 35422901
Associated Longevity Guides & Clinical Calculators
Medicine 3.0Explore comprehensive evidence-based clinical protocols, testing costs, and algorithmic calculators that incorporate Mannose-Binding Lectin (MBL) into overall healthspan optimization.