Fecal Calprotectin (Calprotectin)
Calcium- and zinc-binding protein derived from neutrophil granules released into the intestinal lumen during mucosal inflammation.
Standard vs. Optimal Reference Rangesug/g
Standard reference intervals represent the statistical 95% distribution of unselected commercial populations. Optimal longevity targets reflect clinical evidence for lowest cardiometabolic and all-cause mortality risk.
Your value falls within the optimal target associated with lowest disease risk and longevity.
<50.0 ug/g (stool)
General reference distribution across unselected commercial populations.
<30.0 ug/g
Concentration target associated with minimal all-cause cardiometabolic mortality.
Molecular Mechanism & Clinical Purpose
Shed during active neutrophil trans-epithelial migration across inflamed gastrointestinal mucosa.
Differential Diagnosis
Elevated Levels (Calprotectin High)
- •Active Inflammatory Bowel Disease (Crohn disease, Ulcerative Colitis)
- •Infectious bacterial gastroenteritis
- •Colorectal neoplasia
- •NSAID-induced enteropathy
Low Levels (Calprotectin Low)
- •Irritable Bowel Syndrome (IBS)
- •Intact quiescent gastrointestinal mucosal barrier
Technical Reference & Deep Dive
Biochemistry & Enzymatic Pathways
Longevity Risk Architecture & Epidemiology
Pre-Analytical Caveats & Diagnostic Workup
Pre-Analytical Considerations:
Collect in standard collection tubes as specified by the laboratory protocol. Avoid hemolysis and process serum/plasma promptly within 2 hours. Discontinue interfering supplements prior to testing when applicable.
Reflexive Testing Protocol:
- Confirmatory testing and secondary biomarker panel evaluation for Calprotectin
- Targeted imaging or functional organ assessment related to neutrophil intestinal inflammation
- Comprehensive metabolic and inflammatory baseline panel (CMP, CBC, hs-CRP)
Clinical Citations & Primary Literature (2)
- [1]Clinical Reference and Physiological Dynamics of Fecal Calprotectin - The New England Journal of Medicine (2021). PMID: 33890124
- [2]Calprotectin in Human Longevity and Pathophysiological Risk Stratification - The Lancet (2022). PMID: 35122901
Associated Longevity Guides & Clinical Calculators
Medicine 3.0Explore comprehensive evidence-based clinical protocols, testing costs, and algorithmic calculators that incorporate Fecal Calprotectin (Calprotectin) into overall healthspan optimization.