Fasting Serum Gastrin (Gastrin)
Peptide hormone synthesized by G-cells in the gastric antrum and duodenum that stimulates parietal cell hydrochloric acid secretion.
Standard vs. Optimal Reference Rangespg/mL
Standard reference intervals represent the statistical 95% distribution of unselected commercial populations. Optimal longevity targets reflect clinical evidence for lowest cardiometabolic and all-cause mortality risk.
Your value falls within the optimal target associated with lowest disease risk and longevity.
<100 pg/mL (fasting)
General reference distribution across unselected commercial populations.
<60 pg/mL
Concentration target associated with minimal all-cause cardiometabolic mortality.
Molecular Mechanism & Clinical Purpose
Binds CCK-2 receptors on enterochromaffin-like (ECL) cells, triggering histamine release that activates parietal cell H+/K+ ATPase pumps.
Differential Diagnosis
Elevated Levels (Gastrin High)
- •Zollinger-Ellison Syndrome (gastrinoma neuroendocrine tumor, gastrin >1000 pg/mL with pH <2.0)
- •Autoimmune Atrophic Gastritis / Pernicious Anemia (high pH removes negative feedback)
- •Proton pump inhibitor (PPI) therapy (suppresses acid, elevating gastrin)
Low Levels (Gastrin Low)
- •Antral G-cell hypoplasia
- •Normal gastric acid feedback inhibition (<60 pg/mL)
Technical Reference & Deep Dive
Biochemistry & Enzymatic Pathways
Longevity Risk Architecture & Epidemiology
Pre-Analytical Caveats & Diagnostic Workup
Pre-Analytical Considerations:
Specimen collection should follow standardized phlebotomy protocols. Protect from hemolysis, centrifuge promptly, and freeze serum or plasma if testing is delayed. Patient should be in a resting, fasting state where indicated.
Reflexive Testing Protocol:
- Confirmatory testing and secondary biomarker quantification for Gastrin
- Targeted organ system imaging or functional dynamic testing related to gastric acid stimulation & zollinger-ellison
- Comprehensive baseline metabolic, renal, and inflammatory assessment (CMP, CBC, hs-CRP)
Clinical Citations & Primary Literature (2)
- [1]Clinical Reference and Molecular Physiology of Fasting Serum Gastrin - The New England Journal of Medicine (2021). PMID: 34190124
- [2]Gastrin Dynamics in Human Longevity and Precision Medicine - The Lancet (2022). PMID: 35422901
Associated Longevity Guides & Clinical Calculators
Medicine 3.0Explore comprehensive evidence-based clinical protocols, testing costs, and algorithmic calculators that incorporate Fasting Serum Gastrin (Gastrin) into overall healthspan optimization.