PurpleDaisy Logo
PurpleDaisyResources
BiomarkersReference MatrixLab PanelsCalculatorsCompareGuidesBlog
Download on the App Store
BiomarkersReference MatrixLab PanelsCalculatorsCompareGuidesBlog

Biomarker Encyclopedia

500+ Items
Master Catalogs
  • All 500+ Biomarkers Directory
  • Longevity Reference MatrixPDF
Categories (500+ Markers)
  • Cardiovascular & Lipidology
  • Metabolic & Glycemic Control
  • Renal Physiology & Electrolytes
  • Hepatic & Biliary Function
  • Hematology & CBC
  • Iron Metabolism & Oxygen Transport
  • Endocrinology & Hormones
  • Micronutrients & Vitamins
  • Immunology & Longevity Clocks
Download Meridian on the App Store
Home/Biomarkers/Cardiovascular & Lipidology/Factor XIII
Cardiovascular & LipidologyFibrin Mesh Cross-Linking Transglutaminase

Coagulation Factor XIII Activity (Factor XIII)

Heterotetrameric transglutaminase (A2B2) activated by thrombin and calcium during the terminal phase of the coagulation cascade.

Standard Range70 - 140%
Optimal Longevity80 - 130%
Measurement Unit% Activity
Organ SystemFibrin Mesh Cross-Linking Transglutaminase
Routine Panels:Clot Stability PanelDelayed Bleeding Workup

Standard vs. Optimal Reference Ranges% Activity

Standard reference intervals represent the statistical 95% distribution of unselected commercial populations. Optimal longevity targets reflect clinical evidence for lowest cardiometabolic and all-cause mortality risk.

Interactive Range Analyzer
Unit: % Activity
% Activity
Presets:
49 % ActivityOptimal Zone Target189 % Activity
Optimal Longevity Zone(105 % Activity)

Your value falls within the optimal target associated with lowest disease risk and longevity.

Standard Reference Interval

70 - 140%

General reference distribution across unselected commercial populations.

Optimal Longevity Target

80 - 130%

Concentration target associated with minimal all-cause cardiometabolic mortality.

Molecular Mechanism & Clinical Purpose

Forms covalent gamma-glutamyl-epsilon-lysine bonds between adjacent fibrin monomers and cross-links alpha-2-antiplasmin into the fibrin mesh.

Differential Diagnosis

Elevated Levels (Factor XIII High)

  • •Normal structural clot cross-linking and fibrin stability

Low Levels (Factor XIII Low)

  • •Congenital Factor XIII deficiency (severe delayed bleeding diathesis)
  • •Severe consumptive DIC
  • •Crohn disease with chronic mucosal ulceration

Technical Reference & Deep Dive

Biochemistry & Enzymatic Pathways
At the molecular level, Coagulation Factor XIII Activity (Factor XIII) plays an essential physiological role in fibrin mesh cross-linking transglutaminase. Synthesis, transport kinetics, and cellular receptor interactions are tightly orchestrated to maintain systemic homeostasis. Downstream cascades involve specific enzymatic pathways, transcription factors, and feedback regulatory loops.
Longevity Risk Architecture & Epidemiology
Deficiency causes severe delayed umbilical stump or post-surgical hemorrhage and poor wound healing with completely normal routine PT and aPTT.
Pre-Analytical Caveats & Diagnostic Workup

Pre-Analytical Considerations:

Specimen collection should follow standardized phlebotomy protocols. Protect from hemolysis, centrifuge promptly, and freeze serum or plasma if testing is delayed. Patient should be in a resting, fasting state where indicated.

Reflexive Testing Protocol:

  • Confirmatory testing and secondary biomarker quantification for Factor XIII
  • Targeted organ system imaging or functional dynamic testing related to fibrin mesh cross-linking transglutaminase
  • Comprehensive baseline metabolic, renal, and inflammatory assessment (CMP, CBC, hs-CRP)
Clinical Citations & Primary Literature (2)
  • [1]Clinical Reference and Molecular Physiology of Coagulation Factor XIII Activity - The New England Journal of Medicine (2021). PMID: 34090124
  • [2]Factor XIII Dynamics in Human Longevity and Precision Medicine - The Lancet (2022). PMID: 35322901
Common Panels:Clot Stability PanelDelayed Bleeding Workup
View All Panels

Associated Longevity Guides & Clinical Calculators

Medicine 3.0

Explore comprehensive evidence-based clinical protocols, testing costs, and algorithmic calculators that incorporate Coagulation Factor XIII Activity (Factor XIII) into overall healthspan optimization.

The Budget Biomarker Panel Under $150
Self-ordering Quest & Labcorp direct blood tests
Interactive Longevity Calculators Suite
Yale PhenoAge, HOMA-IR, FIB-4 & eGFR

Related Cardiovascular & Lipidology Biomarkers

High-Sensitivity C-Reactive Protein
hs-CRP · < 0.5 mg/L
Serum Creatinine
Cr · 0.8 - 1.1 mg/dL (stable across time)
Apolipoprotein B
ApoB · < 60 mg/dL (or < 50 mg/dL in high-risk phenotypes)
PreviousCoagulation Factor XI Activity (Factor XI)Cardiovascular & LipidologyNextAnti-NMDA Receptor Antibodies (Anti-NMDAR)Immunology & Longevity Clocks