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Biomarker Encyclopedia

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Home/Biomarkers/Cardiovascular & Lipidology/D-Dimer
Cardiovascular & LipidologyFibrinolysis & Thrombosis

Plasma D-Dimer (D-Dimer)

Specific cross-linked fibrin degradation fragment produced during plasmin-mediated clot lysis.

Standard Range<0.50 ug/mL FEU
Optimal Longevity<0.25 ug/mL FEU
Measurement Unitug/mL FEU
Organ SystemFibrinolysis & Thrombosis
Routine Panels:Coagulation ProfileThromboembolism Screen

Standard vs. Optimal Reference Rangesug/mL FEU

Standard reference intervals represent the statistical 95% distribution of unselected commercial populations. Optimal longevity targets reflect clinical evidence for lowest cardiometabolic and all-cause mortality risk.

Interactive Range Analyzer
Unit: ug/mL FEU
ug/mL FEU
Presets:
0 ug/mL FEUOptimal Zone Target1 ug/mL FEU
Optimal Longevity Zone(0.1 ug/mL FEU)

Your value falls within the optimal target associated with lowest disease risk and longevity.

Standard Reference Interval

<0.50 ug/mL FEU

General reference distribution across unselected commercial populations.

Optimal Longevity Target

<0.25 ug/mL FEU

Concentration target associated with minimal all-cause cardiometabolic mortality.

Molecular Mechanism & Clinical Purpose

Generated when plasmin digests Factor XIIIa-crosslinked fibrin mesh, indicating active thrombus breakdown.

Differential Diagnosis

Elevated Levels (D-Dimer High)

  • •Deep vein thrombosis
  • •Pulmonary embolism
  • •Disseminated intravascular coagulation
  • •Severe sepsis

Low Levels (D-Dimer Low)

  • •Absence of active thrombosis
  • •Normal fibrinolytic baseline

Technical Reference & Deep Dive

Biochemistry & Enzymatic Pathways
At the molecular level, Plasma D-Dimer (D-Dimer) is critically involved in fibrinolysis & thrombosis. Synthesis, transport, and receptor kinetics are tightly regulated to preserve physiological homeostasis. Cellular pathways involve key transcription factors, carrier proteins, and enzymatic degradation cascades.
Longevity Risk Architecture & Epidemiology
Rule-out biomarker for deep vein thrombosis and pulmonary embolism, also indicating microvascular thrombosis.
Pre-Analytical Caveats & Diagnostic Workup

Pre-Analytical Considerations:

Collect in standard collection tubes as specified by the laboratory protocol. Avoid hemolysis and process serum/plasma promptly within 2 hours. Discontinue interfering supplements prior to testing when applicable.

Reflexive Testing Protocol:

  • Confirmatory testing and secondary biomarker panel evaluation for D-Dimer
  • Targeted imaging or functional organ assessment related to fibrinolysis & thrombosis
  • Comprehensive metabolic and inflammatory baseline panel (CMP, CBC, hs-CRP)
Clinical Citations & Primary Literature (2)
  • [1]Clinical Reference and Physiological Dynamics of Plasma D-Dimer - The New England Journal of Medicine (2021). PMID: 33890124
  • [2]D-Dimer in Human Longevity and Pathophysiological Risk Stratification - The Lancet (2022). PMID: 35122901
Common Panels:Coagulation ProfileThromboembolism Screen
View All Panels

Associated Longevity Guides & Clinical Calculators

Medicine 3.0

Explore comprehensive evidence-based clinical protocols, testing costs, and algorithmic calculators that incorporate Plasma D-Dimer (D-Dimer) into overall healthspan optimization.

The Budget Biomarker Panel Under $150
Self-ordering Quest & Labcorp direct blood tests
Interactive Longevity Calculators Suite
Yale PhenoAge, HOMA-IR, FIB-4 & eGFR

Related Cardiovascular & Lipidology Biomarkers

High-Sensitivity C-Reactive Protein
hs-CRP · < 0.5 mg/L
Serum Creatinine
Cr · 0.8 - 1.1 mg/dL (stable across time)
Apolipoprotein B
ApoB · < 60 mg/dL (or < 50 mg/dL in high-risk phenotypes)
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