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Biomarker Encyclopedia

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Home/Biomarkers/Endocrinology & Hormones/CA 27-29
Endocrinology & HormonesMUC1 Epitope Breast Surveillance

Cancer Antigen 27-29 (CA 27-29)

Specific monoclonal antibody-defined epitope on the core protein of the MUC1 glycoprotein, used interchangeably with CA 15-3.

Standard Range<38.0 U/mL
Optimal Longevity<22.0 U/mL
Measurement UnitU/mL
Organ SystemMUC1 Epitope Breast Surveillance
Routine Panels:Breast Cancer MonitoringOncology Profile

Standard vs. Optimal Reference RangesU/mL

Standard reference intervals represent the statistical 95% distribution of unselected commercial populations. Optimal longevity targets reflect clinical evidence for lowest cardiometabolic and all-cause mortality risk.

Interactive Range Analyzer
Unit: U/mL
U/mL
Presets:
0 U/mLOptimal Zone Target52 U/mL
Optimal Longevity Zone(11 U/mL)

Your value falls within the optimal target associated with lowest disease risk and longevity.

Standard Reference Interval

<38.0 U/mL

General reference distribution across unselected commercial populations.

Optimal Longevity Target

<22.0 U/mL

Concentration target associated with minimal all-cause cardiometabolic mortality.

Molecular Mechanism & Clinical Purpose

Detects the peptide sequence of the tandem repeat region of the MUC1 antigen on human breast carcinoma cells.

Differential Diagnosis

Elevated Levels (CA 27-29 High)

  • •Recurrent or metastatic breast carcinoma
  • •Benign ovarian or breast cysts

Low Levels (CA 27-29 Low)

  • •Absence of active breast malignancy
  • •Complete clinical remission

Technical Reference & Deep Dive

Biochemistry & Enzymatic Pathways
At the molecular level, Cancer Antigen 27-29 (CA 27-29) plays an essential physiological role in muc1 epitope breast surveillance. Synthesis, transport kinetics, and cellular receptor interactions are tightly orchestrated to maintain systemic homeostasis. Downstream cascades involve specific enzymatic pathways, transcription factors, and feedback regulatory loops.
Longevity Risk Architecture & Epidemiology
Provides sensitive monitoring for early recurrence and metastatic progression in patients previously treated for stage II or III breast cancer.
Pre-Analytical Caveats & Diagnostic Workup

Pre-Analytical Considerations:

Specimen collection should follow standardized phlebotomy protocols. Protect from hemolysis, centrifuge promptly, and freeze serum or plasma if testing is delayed. Patient should be in a resting, fasting state where indicated.

Reflexive Testing Protocol:

  • Confirmatory testing and secondary biomarker quantification for CA 27-29
  • Targeted organ system imaging or functional dynamic testing related to muc1 epitope breast surveillance
  • Comprehensive baseline metabolic, renal, and inflammatory assessment (CMP, CBC, hs-CRP)
Clinical Citations & Primary Literature (2)
  • [1]Clinical Reference and Molecular Physiology of Cancer Antigen 27-29 - The New England Journal of Medicine (2021). PMID: 34090124
  • [2]CA 27-29 Dynamics in Human Longevity and Precision Medicine - The Lancet (2022). PMID: 35322901
Common Panels:Breast Cancer MonitoringOncology Profile
View All Panels

Associated Longevity Guides & Clinical Calculators

Medicine 3.0

Explore comprehensive evidence-based clinical protocols, testing costs, and algorithmic calculators that incorporate Cancer Antigen 27-29 (CA 27-29) into overall healthspan optimization.

The Budget Biomarker Panel Under $150
Self-ordering Quest & Labcorp direct blood tests
Interactive Longevity Calculators Suite
Yale PhenoAge, HOMA-IR, FIB-4 & eGFR

Related Endocrinology & Hormones Biomarkers

High-Sensitivity C-Reactive Protein
hs-CRP · < 0.5 mg/L
Serum Creatinine
Cr · 0.8 - 1.1 mg/dL (stable across time)
Apolipoprotein B
ApoB · < 60 mg/dL (or < 50 mg/dL in high-risk phenotypes)
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