Asymmetric Dimethylarginine (ADMA)
Endogenous methylated arginine derivative that acts as a potent competitive inhibitor of nitric oxide synthase.
Standard vs. Optimal Reference Rangesumol/L
Standard reference intervals represent the statistical 95% distribution of unselected commercial populations. Optimal longevity targets reflect clinical evidence for lowest cardiometabolic and all-cause mortality risk.
Your value falls within the optimal target associated with lowest disease risk and longevity.
0.40 - 0.70 umol/L
General reference distribution across unselected commercial populations.
<0.50 umol/L
Concentration target associated with minimal all-cause cardiometabolic mortality.
Molecular Mechanism & Clinical Purpose
Competes with L-arginine for eNOS binding, uncoupling eNOS to produce superoxide instead of nitric oxide.
Differential Diagnosis
Elevated Levels (ADMA High)
- •End-stage renal disease
- •Hypercholesterolemia
- •Diabetes mellitus
- •Chronic kidney disease
Low Levels (ADMA Low)
- •High endothelial nitric oxide synthesis
- •Optimal microvascular perfusion
Technical Reference & Deep Dive
Biochemistry & Enzymatic Pathways
Longevity Risk Architecture & Epidemiology
Pre-Analytical Caveats & Diagnostic Workup
Pre-Analytical Considerations:
Collect in standard collection tubes as specified by the laboratory protocol. Avoid hemolysis and process serum/plasma promptly within 2 hours. Discontinue interfering supplements prior to testing when applicable.
Reflexive Testing Protocol:
- Confirmatory testing and secondary biomarker panel evaluation for ADMA
- Targeted imaging or functional organ assessment related to nitric oxide bioavailability
- Comprehensive metabolic and inflammatory baseline panel (CMP, CBC, hs-CRP)
Clinical Citations & Primary Literature (2)
- [1]Clinical Reference and Physiological Dynamics of Asymmetric Dimethylarginine - The New England Journal of Medicine (2021). PMID: 33890124
- [2]ADMA in Human Longevity and Pathophysiological Risk Stratification - The Lancet (2022). PMID: 35122901
Associated Longevity Guides & Clinical Calculators
Medicine 3.0Explore comprehensive evidence-based clinical protocols, testing costs, and algorithmic calculators that incorporate Asymmetric Dimethylarginine (ADMA) into overall healthspan optimization.