Apolipoprotein E Phenotype (ApoE)
Multifunctional apolipoprotein mediating receptor binding of chylomicrons and VLDL remnants, impacting Alzheimer risk.
Standard vs. Optimal Reference Rangesmg/dL
Standard reference intervals represent the statistical 95% distribution of unselected commercial populations. Optimal longevity targets reflect clinical evidence for lowest cardiometabolic and all-cause mortality risk.
Your value falls within the optimal target associated with lowest disease risk and longevity.
2.5 - 5.0 mg/dL (E3/E3 common)
General reference distribution across unselected commercial populations.
3.0 - 4.5 mg/dL
Concentration target associated with minimal all-cause cardiometabolic mortality.
Molecular Mechanism & Clinical Purpose
Acts as high-affinity ligand for LDL receptors and LRP1; ApoE4 exhibits impaired amyloid-beta clearance.
Differential Diagnosis
Elevated Levels (ApoE High)
- •Type III hyperlipoproteinemia (E2/E2)
- •ApoE4-associated accelerated atherosclerosis
Low Levels (ApoE Low)
- •ApoE2-associated low LDL-C
- •Optimal chylomicron remnant clearance
Technical Reference & Deep Dive
Biochemistry & Enzymatic Pathways
Longevity Risk Architecture & Epidemiology
Pre-Analytical Caveats & Diagnostic Workup
Pre-Analytical Considerations:
Collect in standard collection tubes as specified by the laboratory protocol. Avoid hemolysis and process serum/plasma promptly within 2 hours. Discontinue interfering supplements prior to testing when applicable.
Reflexive Testing Protocol:
- Confirmatory testing and secondary biomarker panel evaluation for ApoE
- Targeted imaging or functional organ assessment related to lipoprotein clearance & neurobiology
- Comprehensive metabolic and inflammatory baseline panel (CMP, CBC, hs-CRP)
Clinical Citations & Primary Literature (2)
- [1]Clinical Reference and Physiological Dynamics of Apolipoprotein E Phenotype - The New England Journal of Medicine (2021). PMID: 33890124
- [2]ApoE in Human Longevity and Pathophysiological Risk Stratification - The Lancet (2022). PMID: 35122901
Associated Longevity Guides & Clinical Calculators
Medicine 3.0Explore comprehensive evidence-based clinical protocols, testing costs, and algorithmic calculators that incorporate Apolipoprotein E Phenotype (ApoE) into overall healthspan optimization.