Anti-Double-Stranded DNA (Anti-dsDNA)
High-affinity autoantibodies targeting the phosphodiester backbone of double-stranded DNA.
Standard vs. Optimal Reference RangesIU/mL
Standard reference intervals represent the statistical 95% distribution of unselected commercial populations. Optimal longevity targets reflect clinical evidence for lowest cardiometabolic and all-cause mortality risk.
Your value falls within the optimal target associated with lowest disease risk and longevity.
<30.0 IU/mL
General reference distribution across unselected commercial populations.
<10.0 IU/mL (negative)
Concentration target associated with minimal all-cause cardiometabolic mortality.
Molecular Mechanism & Clinical Purpose
Deposits in glomerular basement membranes, activating complement and driving immune complex-mediated lupus nephritis.
Differential Diagnosis
Elevated Levels (Anti-dsDNA High)
- •Systemic Lupus Erythematosus (SLE)
- •Active Lupus Nephritis flare
- •Drug-induced lupus (rare)
Low Levels (Anti-dsDNA Low)
- •Quiescent autoimmune disease
- •Clinical SLE remission
Technical Reference & Deep Dive
Biochemistry & Enzymatic Pathways
Longevity Risk Architecture & Epidemiology
Pre-Analytical Caveats & Diagnostic Workup
Pre-Analytical Considerations:
Collect in standard collection tubes as specified by the laboratory protocol. Avoid hemolysis and process serum/plasma promptly within 2 hours. Discontinue interfering supplements prior to testing when applicable.
Reflexive Testing Protocol:
- Confirmatory testing and secondary biomarker panel evaluation for Anti-dsDNA
- Targeted imaging or functional organ assessment related to systemic lupus erythematosus
- Comprehensive metabolic and inflammatory baseline panel (CMP, CBC, hs-CRP)
Clinical Citations & Primary Literature (2)
- [1]Clinical Reference and Physiological Dynamics of Anti-Double-Stranded DNA - The New England Journal of Medicine (2021). PMID: 33890124
- [2]Anti-dsDNA in Human Longevity and Pathophysiological Risk Stratification - The Lancet (2022). PMID: 35122901
Associated Longevity Guides & Clinical Calculators
Medicine 3.0Explore comprehensive evidence-based clinical protocols, testing costs, and algorithmic calculators that incorporate Anti-Double-Stranded DNA (Anti-dsDNA) into overall healthspan optimization.