11-Deoxycorticosterone (11-DOC)
Potent intermediate mineralocorticoid steroid synthesized from progesterone via 21-hydroxylase in the adrenal cortex.
Standard vs. Optimal Reference Rangesng/dL
Standard reference intervals represent the statistical 95% distribution of unselected commercial populations. Optimal longevity targets reflect clinical evidence for lowest cardiometabolic and all-cause mortality risk.
Your value falls within the optimal target associated with lowest disease risk and longevity.
2 - 15 ng/dL
General reference distribution across unselected commercial populations.
3 - 10 ng/dL
Concentration target associated with minimal all-cause cardiometabolic mortality.
Molecular Mechanism & Clinical Purpose
Possesses strong intrinsic mineralocorticoid activity at the MR receptor; converted to corticosterone by CYP11B1.
Differential Diagnosis
Elevated Levels (11-DOC High)
- •11beta-hydroxylase deficiency
- •17alpha-hydroxylase deficiency
- •DOC-producing adrenal adenoma
- •Severe low-renin hypertension
Low Levels (11-DOC Low)
- •21-hydroxylase deficiency
- •Primary Addison disease
Technical Reference & Deep Dive
Biochemistry & Enzymatic Pathways
Longevity Risk Architecture & Epidemiology
Pre-Analytical Caveats & Diagnostic Workup
Pre-Analytical Considerations:
Specimen collection should follow standardized phlebotomy protocols. Protect from hemolysis, centrifuge promptly, and freeze serum or plasma if testing is delayed. Patient should be in a resting, fasting state where indicated.
Reflexive Testing Protocol:
- Confirmatory testing and secondary biomarker quantification for 11-DOC
- Targeted organ system imaging or functional dynamic testing related to mineralocorticoid precursor flux
- Comprehensive baseline metabolic, renal, and inflammatory assessment (CMP, CBC, hs-CRP)
Clinical Citations & Primary Literature (2)
- [1]Clinical Reference and Molecular Physiology of 11-Deoxycorticosterone - The New England Journal of Medicine (2021). PMID: 33990124
- [2]11-DOC Dynamics in Human Longevity and Precision Medicine - The Lancet (2022). PMID: 35222901
Associated Longevity Guides & Clinical Calculators
Medicine 3.0Explore comprehensive evidence-based clinical protocols, testing costs, and algorithmic calculators that incorporate 11-Deoxycorticosterone (11-DOC) into overall healthspan optimization.